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AB132722

Recombinant Human SDCCAG8 protein (GST tag N-Terminus)

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Recombinant Human SDCCAG8 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 360 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CCCAP, NPHP10, HSPC085, SDCCAG8, Serologically defined colon cancer antigen 8, Antigen NY-CO-8, Centrosomal colon cancer autoantigen protein, hCCCAP

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SDS-PAGE - Recombinant Human SDCCAG8 protein (GST tag N-Terminus) (AB132722)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SDCCAG8 protein (GST tag N-Terminus) (AB132722)

12.5% SDS-PAGE analysis of ab132722 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q86SQ7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB228891

Anti-SDCCAG8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKHPSQ","proteinLength":"Full Length","predictedMolecularWeight":"67.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":360,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86SQ7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDCCAG8 also known as Serologically Defined Colon Cancer Antigen 8 is a protein weighing approximately 92 kDa. This protein localizes primarily to centrosomes and cilia within the cell. SDCCAG8 gets expressed in many tissues with notable expression in the ciliated cells of the respiratory tract. The protein plays roles in centrosomal organization and the regulation of cilia formation.
Biological function summary

This protein has key roles in cell division and ciliogenesis due to its interaction with other proteins involved in these processes. SDCCAG8 is part of a protein complex that is important for stabilizing centrosomes and promoting proper ciliogenesis. It interacts with centriolar proteins affecting cellular structure and function. Through these interactions SDCCAG8 supports cell cycle progression and normal cellular signaling.

Pathways

SDCCAG8 participates in the centrosome-cilium interface impacting cell division and signaling pathways such as Wnt and Hedgehog. SDCCAG8 collaborates with proteins like OFD1 and CEP290 which contribute to the integrity of these pathways. These associations ensure accurate cellular signaling and distribution of cellular components during mitosis.

SDCCAG8 mutations have been linked to disorders such as Bardet-Biedl syndrome and related ciliopathies. These diseases often involve symptoms like retinal degeneration and polydactyly. The protein's association with others like BBS4 and BBS1 highlights its involvement in the pathological mechanisms of these conditions by affecting the structure and signaling capacity of cilia.
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Specifications

Form

Liquid

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General info

Function

Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed : 27224062).

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Product protocols

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Target data

Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed : 27224062).
See full target information SDCCAG8
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Product promise

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