JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB181895

Recombinant Human SDF2 protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human SDF2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 19 to 211 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Stromal cell-derived factor 2, SDF-2, SDF2

1 Images
SDS-PAGE - Recombinant Human SDF2 protein (denatured) (His tag N-Terminus) (AB181895)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SDF2 protein (denatured) (His tag N-Terminus) (AB181895)

15% SDS-PAGE analysis of 3μg ab181895.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q99470

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSSSLGVVTCGSVVKLLNTRHNVRLHSHDVRYGSGSGQQSVTGVTSVDDSNSYWRIRGKSATVCERGTPIKCGQPIRLTHVNTGRNLHSHHFTSPLSGNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIFMKPSELLKAEAHHAEL","proteinLength":"Full Length","predictedMolecularWeight":"23.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":211,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99470","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDF2 also known as Stromal Cell-Derived Factor 2 is a protein with a mass of approximately 23 kDa. It functions mechanically as a molecular chaperone involved in protein folding within the endoplasmic reticulum (ER). This protein is ubiquitously expressed in multiple tissues with higher expression in secretory cells indicating its involvement in handling protein load associated with secretion. SDF2 facilitates the processing and assembly of other proteins maintaining their correct conformation.
Biological function summary

SDF2 assists in the development and maintenance of protein homeostasis within the ER. It plays a part in the ER-associated degradation (ERAD) pathway ensuring that misfolded or improperly assembled proteins are targeted for degradation. SDF2 is part of a larger complex with other chaperone proteins. This function helps mitigate ER stress by preventing the accumulation of defective proteins which could disrupt cellular function.

Pathways

SDF2 operates within the broader framework of the unfolded protein response (UPR) and ER stress pathways. It assists in the modulation of these pathways by interacting with other chaperones like calnexin and BiP (Binding Immunoglobulin Protein). This interaction helps optimize protein folding conditions under stress conditions. SDF2 contributes to maintaining cellular balance by supporting efficient degradation and preventing aggregation of unfolded proteins.

SDF2 is linked to conditions like neurodegenerative diseases and cancer. Impaired chaperone activities or ER stress can lead to protein aggregation which is a hallmark of maladies such as Alzheimer's disease. In cancer altered levels of SDF2 expression have been noted which might affect cellular proliferation and survival under stress. Its relationship with other ER stress-related proteins like IRE1 further elucidates its role in pathogenesis.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

style
left-column

Product protocols

style
left-column

Target data

See full target information SDF2
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB183259

Recombinant Human TSR2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TSR2 protein (AB183259)

  • 0
  • 0
Proteins & Peptides

AB181931

Recombinant Human THAP7 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)

  • 0
  • 0
Proteins & Peptides

AB181920

Recombinant Human TRBP protein (denatured) (Tag Free)

SDS-PAGE - Recombinant Human TRBP protein (denatured) (Tag Free) (AB181920)

  • 0
  • 0
Proteins & Peptides

AB181934

Recombinant Human ZNF32 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (His tag N-Terminus) (AB181934)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com