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AB162434

Recombinant Human SDF4 protein

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Recombinant Human SDF4 protein is a Human Full Length protein, in the 1 to 362 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CAB45, PSEC0034, SDF4, 45 kDa calcium-binding protein, Cab45, Stromal cell-derived factor 4, SDF-4

1 Images
SDS-PAGE - Recombinant Human SDF4 protein (AB162434)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human SDF4 protein (AB162434)

ab162434 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9BRK5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVWPWVAMASRWGPLIGLAPCCLWLLGAVLLMDASARPANHSSTRERVANREENEILPPDHLNGVKLEMDGHLNRGFHQEVFLGKDLGGFDEDAEPRRSRRKLMVIFSKVDVNTDRKISAKEMQRWIMEKTAEHFQEAMEESKTHFRAVDPDGDGHVSWDEYKVKFLASKGHSEKEVADAIRLNEELKVDEETQEVLENLKDRWYQADSPPADLLLTEEEFLSFLHPEHSRGMLRFMVKEIVRDLDQDGDKQLSVPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTAEELESYMDPMNEYNALNEAKQMIAVADENQNHHLEPEEVLKYSEFFTGSKLVDYARSVHEEF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":362,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BRK5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDF4 also known as Stromal Cell Derived Factor 4 or Cab45 is a calcium-binding protein with a molecular mass of approximately 45 kDa. It is expressed in the Golgi apparatus of cells in various tissues including pancreas liver and brain. SDF4 plays a mechanical role in sorting and trafficking of proteins through the secretory pathway specifically during the transport of secretory cargo in the Golgi.
Biological function summary

This protein participates in the regulation of calcium-dependent vesicle transport. It does not function as part of a large protein complex but interacts with different proteins in the Golgi for sorting activities. SDF4's ability to bind calcium allows it to modulate interactions necessary for vesicle movement and cargo recognition affecting how proteins exit the Golgi and are distributed to other areas of the cell.

Pathways

Studies show SDF4 is involved in the cellular secretory pathway and calcium signaling pathway. Within these pathways SDF4 interacts with proteins like co-chaperone SIL1 to ensure proper protein folding and trafficking. SDF4 also contributes to vesicle budding processes that are essential for maintaining proper cellular function and homeostasis.

Dysfunction of SDF4 links to disorders such as diabetes and neurodegenerative diseases. Abnormal SDF4 expression impacts proteins like insulin in the pancreatic pathway contributing to diabetes through misfolding or improper secretion of insulin. In neurodegenerative conditions SDF4's disrupted association with proteins involved in calcium homeostasis affects synaptic function and neuron health implicating it in diseases like Alzheimer's.
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Specifications

Form

Liquid

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General info

Function

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

Sequence similarities

Belongs to the CREC family.

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Product protocols

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Target data

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
See full target information SDF4
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