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AB161678

Recombinant Human SEC14 like protein 2 (GST tag N-Terminus)

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Recombinant Human SEC14 like protein 2 (GST tag N-Terminus) is a Human Fragment protein, in the 101 to 199 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C22orf6, KIAA1186, KIAA1658, SEC14L2, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor, TAP, hTAP, SPF

1 Images
SDS-PAGE - Recombinant Human SEC14 like protein 2 (GST tag N-Terminus) (AB161678)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SEC14 like protein 2 (GST tag N-Terminus) (AB161678)

ab161678 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O76054

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Primary Antibodies

AB137013

Anti-SEC14L2/TAP antibody [EPR8612]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC14L2/TAP antibody [EPR8612] (AB137013)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB161165

Recombinant Human WASF3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human WASF3 protein (GST tag N-Terminus) (AB161165)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFP","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":101,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O76054","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEC14 like protein 2 also known as SEC14L2 participates in lipid binding and transport. This protein weighs about 45 kDa and plays a role in lipid metabolism. Expression of SEC14L2 can be found in multiple tissues including the liver and spleen. By interacting with lipids SEC14L2 modulates cellular lipid environments and influences various cellular processes.
Biological function summary

This protein interacts with other lipid transfer proteins and is involved in lipid homeostasis. SEC14L2 does not act alone; it often forms part of lipid protein complexes that facilitate the transport of lipids across biological membranes. These complexes enable SEC14L2 to contribute to the maintenance of membrane integrity and facilitate signal transduction pathways.

Pathways

This protein participates in lipid metabolism and phosphatidylinositide signaling pathways. In the regulation of these pathways SEC14L2 interacts with proteins like phosphatidylinositol 3-kinase (PI3K). Through these interactions SEC14L2 supports critical cellular functions such as membrane trafficking and signaling that depend on lipid dynamics.

Research links SEC14L2 to liver diseases like hepatitis C and its expression influences antiviral defense mechanisms. Additionally SEC14L2 associates with proteins involved in cholesterol metabolism contributing to atherosclerosis development. By understanding SEC14L2's role researchers aim to find therapeutic targets for these conditions.
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Specifications

Form

Liquid

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General info

Function

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
See full target information SEC14L2
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