Recombinant Human Sec24C protein is a Human Full Length protein, in the 1 to 1094 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
M N V N Q S V P P V P P F G Q P Q P I Y P G Y H Q S S Y G G Q S G S T A P A I P Y G A Y N G P V P G Y Q Q T P P Q G M S R A P P S S G A P P A S T A Q A P C G Q A A Y G Q F G Q G D V Q N G P S S T V Q M Q R L P G S Q S F G S P L A P V G N Q P P V L Q P Y G P P P T S A Q V A T Q L S G M Q I S G A V A P A P P S S G L G F G P P T S L A S A S G S F P N S G L Y G S Y P Q G Q A P P L S Q A Q G H P G I Q T P Q R S A P S Q A S S F T P P A S G G P R L P S M T G P L L P G Q S F G G P S V S Q P N H V S S P P Q A L P P G T Q M T G P L G P L P P M H S P Q Q P G Y Q P Q Q N G S F G P A R G P Q S N Y G G P Y P A A P T F G S Q P G P P Q P L P P K R L D P D A I P S P I Q V I E D D R N N R G T E P F V T G V R G Q V P P L V T T N F L V K D Q G N A S P R Y I R C T S Y N I P C T S D M A K Q A Q V P L A A V I K P L A R L P P E E A S P Y V V D H G E S G P L R C N R C K A Y M C P F M Q F I E G G R R F Q C C F C S C I N D V P P Q Y F Q H L D H T G K R V D A Y D R P E L S L G S Y E F L A T V D Y C K N N K F P S P P A F I F M I D V S Y N A I R T G L V R L L C E E L K S L L D F L P R E G G A E E S A I R V G F V T Y N K V L H F Y N V K S S L A Q P Q M M V V S D V A D M F V P L L D G F L V N V N E S R A V I T S L L D Q I P E M F A D T R E T E T V F V P V I Q A G M E A L K A A E C A G K L F L F H T S L P I A E A P G K L K N R D D R K L I N T D K E K T L F Q P Q T G A Y Q T L A K E C V A Q G C C V D L F L F P N Q Y V D V A T L S V V P Q L T G G S V Y K Y A S F Q V E N D Q E R F L S D L R R D V Q K V V G F D A V M R V R T S T G I R A V D F F G A F Y M S N T T D V E L A G L D G D K T V T V E F K H D D R L N E E S G A L L Q C A L L Y T S C A G Q R R L R I H N L A L N C C T Q L A D L Y R N C E T D T L I N Y M A K F A Y R G V L N S P V K A V R D T L I T Q C A Q I L A C Y R K N C A S P S S A G Q L I L P E C M K L L P V Y L N C V L K S D V L Q P G A E V T T D D R A Y V R Q L V T S M D V T E T N V F F Y P R L L P L T K S P V E S T T E P P A V R A S E E R L S N G D I Y L L E N G L N L F L W V G A S V Q Q G V V Q S L F S V S S F S Q I T S G L S V L P V L D N P L S K K V R G L I D S L R A Q R S R Y M K L T V V K Q E D K M E M L F K H F L V E D K S L S G G A S Y V D F L C H M H K E I R Q L L S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
Alternative names
Protein transport protein Sec24C, SEC24-related protein C, KIAA0079, SEC24C
Recommended products
Recombinant Human Sec24C protein is a Human Full Length protein, in the 1 to 1094 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Alternative names
Protein transport protein Sec24C, SEC24-related protein C, KIAA0079, SEC24C
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- P53992-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
M N V N Q S V P P V P P F G Q P Q P I Y P G Y H Q S S Y G G Q S G S T A P A I P Y G A Y N G P V P G Y Q Q T P P Q G M S R A P P S S G A P P A S T A Q A P C G Q A A Y G Q F G Q G D V Q N G P S S T V Q M Q R L P G S Q S F G S P L A P V G N Q P P V L Q P Y G P P P T S A Q V A T Q L S G M Q I S G A V A P A P P S S G L G F G P P T S L A S A S G S F P N S G L Y G S Y P Q G Q A P P L S Q A Q G H P G I Q T P Q R S A P S Q A S S F T P P A S G G P R L P S M T G P L L P G Q S F G G P S V S Q P N H V S S P P Q A L P P G T Q M T G P L G P L P P M H S P Q Q P G Y Q P Q Q N G S F G P A R G P Q S N Y G G P Y P A A P T F G S Q P G P P Q P L P P K R L D P D A I P S P I Q V I E D D R N N R G T E P F V T G V R G Q V P P L V T T N F L V K D Q G N A S P R Y I R C T S Y N I P C T S D M A K Q A Q V P L A A V I K P L A R L P P E E A S P Y V V D H G E S G P L R C N R C K A Y M C P F M Q F I E G G R R F Q C C F C S C I N D V P P Q Y F Q H L D H T G K R V D A Y D R P E L S L G S Y E F L A T V D Y C K N N K F P S P P A F I F M I D V S Y N A I R T G L V R L L C E E L K S L L D F L P R E G G A E E S A I R V G F V T Y N K V L H F Y N V K S S L A Q P Q M M V V S D V A D M F V P L L D G F L V N V N E S R A V I T S L L D Q I P E M F A D T R E T E T V F V P V I Q A G M E A L K A A E C A G K L F L F H T S L P I A E A P G K L K N R D D R K L I N T D K E K T L F Q P Q T G A Y Q T L A K E C V A Q G C C V D L F L F P N Q Y V D V A T L S V V P Q L T G G S V Y K Y A S F Q V E N D Q E R F L S D L R R D V Q K V V G F D A V M R V R T S T G I R A V D F F G A F Y M S N T T D V E L A G L D G D K T V T V E F K H D D R L N E E S G A L L Q C A L L Y T S C A G Q R R L R I H N L A L N C C T Q L A D L Y R N C E T D T L I N Y M A K F A Y R G V L N S P V K A V R D T L I T Q C A Q I L A C Y R K N C A S P S S A G Q L I L P E C M K L L P V Y L N C V L K S D V L Q P G A E V T T D D R A Y V R Q L V T S M D V T E T N V F F Y P R L L P L T K S P V E S T T E P P A V R A S E E R L S N G D I Y L L E N G L N L F L W V G A S V Q Q G V V Q S L F S V S S F S Q I T S G L S V L P V L D N P L S K K V R G L I D S L R A Q R S R Y M K L T V V K Q E D K M E M L F K H F L V E D K S L S G G A S Y V D F L C H M H K E I R Q L L S
- Accession
- Protein length
Full Length
- Amino acids
1 to 1094
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
- Sequence similarities
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
U+00A0;
U+00A0;
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein Sec24C also known as SEC24 family member C functions in vesicular trafficking. It belongs to the COPII coat complex which plays a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. Sec24C is part of a family with a molecular mass of approximately 125 kDa and it is ubiquitously expressed in various tissues suggesting an essential role in cellular transport mechanisms.
- Biological function summary
Sec24C is involved in the formation of COPII-coated vesicles which are essential for the anterograde transport of proteins. It serves as a cargo adaptor within the COPII complex consisting also of proteins such as Sec23 Sec13 and Sec31. The interaction of Sec24C with these proteins ensures the proper selection and packaging of cargo during vesicle budding therefore maintaining effective intracellular transport.
- Pathways
Sec24C plays a role in the secretory pathway and is involved in the ER-to-Golgi transport. It functions in collaboration with other COPII components facilitating the packaging and movement of secretory proteins. Key proteins associated with this pathways include Sar1 and Sec23 which coordinate with Sec24C to regulate vesicle formation and cargo selection efficiently.
- Associated diseases and disorders
Disruptions in Sec24C function have been linked to neurological conditions such as Alzheimer's disease and certain forms of neurodegeneration. Altered Sec24C activity affects vesicle trafficking and protein processing interacting with proteins like APP (Amyloid precursor protein) which may lead to pathology. Understanding the role of Sec24C and its interactions could offer insights into therapeutic strategies for these diseases.
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1 product image
SDS-PAGE - Recombinant Human Sec24C protein (ab160588)
ab160588 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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