Recombinant Human Sec24C protein is a Human Full Length protein, in the 1 to 1094 aa range, expressed in Wheat germ and suitable for ELISA, WB.
M N V N Q S V P P V P P F G Q P Q P I Y P G Y H Q S S Y G G Q S G S T A P A I P Y G A Y N G P V P G Y Q Q T P P Q G M S R A P P S S G A P P A S T A Q A P C G Q A A Y G Q F G Q G D V Q N G P S S T V Q M Q R L P G S Q S F G S P L A P V G N Q P P V L Q P Y G P P P T S A Q V A T Q L S G M Q I S G A V A P A P P S S G L G F G P P T S L A S A S G S F P N S G L Y G S Y P Q G Q A P P L S Q A Q G H P G I Q T P Q R S A P S Q A S S F T P P A S G G P R L P S M T G P L L P G Q S F G G P S V S Q P N H V S S P P Q A L P P G T Q M T G P L G P L P P M H S P Q Q P G Y Q P Q Q N G S F G P A R G P Q S N Y G G P Y P A A P T F G S Q P G P P Q P L P P K R L D P D A I P S P I Q V I E D D R N N R G T E P F V T G V R G Q V P P L V T T N F L V K D Q G N A S P R Y I R C T S Y N I P C T S D M A K Q A Q V P L A A V I K P L A R L P P E E A S P Y V V D H G E S G P L R C N R C K A Y M C P F M Q F I E G G R R F Q C C F C S C I N D V P P Q Y F Q H L D H T G K R V D A Y D R P E L S L G S Y E F L A T V D Y C K N N K F P S P P A F I F M I D V S Y N A I R T G L V R L L C E E L K S L L D F L P R E G G A E E S A I R V G F V T Y N K V L H F Y N V K S S L A Q P Q M M V V S D V A D M F V P L L D G F L V N V N E S R A V I T S L L D Q I P E M F A D T R E T E T V F V P V I Q A G M E A L K A A E C A G K L F L F H T S L P I A E A P G K L K N R D D R K L I N T D K E K T L F Q P Q T G A Y Q T L A K E C V A Q G C C V D L F L F P N Q Y V D V A T L S V V P Q L T G G S V Y K Y A S F Q V E N D Q E R F L S D L R R D V Q K V V G F D A V M R V R T S T G I R A V D F F G A F Y M S N T T D V E L A G L D G D K T V T V E F K H D D R L N E E S G A L L Q C A L L Y T S C A G Q R R L R I H N L A L N C C T Q L A D L Y R N C E T D T L I N Y M A K F A Y R G V L N S P V K A V R D T L I T Q C A Q I L A C Y R K N C A S P S S A G Q L I L P E C M K L L P V Y L N C V L K S D V L Q P G A E V T T D D R A Y V R Q L V T S M D V T E T N V F F Y P R L L P L T K S P V E S T T E P P A V R A S E E R L S N G D I Y L L E N G L N L F L W V G A S V Q Q G V V Q S L F S V S S F S Q I T S G L S V L P V L D N P L S K K V R G L I D S L R A Q R S R Y M K L T V V K Q E D K M E M L F K H F L V E D K S L S G G A S Y V D F L C H M H K E I R Q L L S
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
KIAA0079, SEC24C, Protein transport protein Sec24C, SEC24-related protein C
Recombinant Human Sec24C protein is a Human Full Length protein, in the 1 to 1094 aa range, expressed in Wheat germ and suitable for ELISA, WB.
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
The protein Sec24C also known as SEC24 family member C functions in vesicular trafficking. It belongs to the COPII coat complex which plays a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. Sec24C is part of a family with a molecular mass of approximately 125 kDa and it is ubiquitously expressed in various tissues suggesting an essential role in cellular transport mechanisms.
Sec24C is involved in the formation of COPII-coated vesicles which are essential for the anterograde transport of proteins. It serves as a cargo adaptor within the COPII complex consisting also of proteins such as Sec23 Sec13 and Sec31. The interaction of Sec24C with these proteins ensures the proper selection and packaging of cargo during vesicle budding therefore maintaining effective intracellular transport.
Sec24C plays a role in the secretory pathway and is involved in the ER-to-Golgi transport. It functions in collaboration with other COPII components facilitating the packaging and movement of secretory proteins. Key proteins associated with this pathways include Sar1 and Sec23 which coordinate with Sec24C to regulate vesicle formation and cargo selection efficiently.
Disruptions in Sec24C function have been linked to neurological conditions such as Alzheimer's disease and certain forms of neurodegeneration. Altered Sec24C activity affects vesicle trafficking and protein processing interacting with proteins like APP (Amyloid precursor protein) which may lead to pathology. Understanding the role of Sec24C and its interactions could offer insights into therapeutic strategies for these diseases.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab160588 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com