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AB160588

Recombinant Human Sec24C protein

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Recombinant Human Sec24C protein is a Human Full Length protein, in the 1 to 1094 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0079, SEC24C, Protein transport protein Sec24C, SEC24-related protein C

1 Images
SDS-PAGE - Recombinant Human Sec24C protein (AB160588)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Sec24C protein (AB160588)

ab160588 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P53992

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQSFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":1094,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P53992","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Sec24C also known as SEC24 family member C functions in vesicular trafficking. It belongs to the COPII coat complex which plays a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. Sec24C is part of a family with a molecular mass of approximately 125 kDa and it is ubiquitously expressed in various tissues suggesting an essential role in cellular transport mechanisms.
Biological function summary

Sec24C is involved in the formation of COPII-coated vesicles which are essential for the anterograde transport of proteins. It serves as a cargo adaptor within the COPII complex consisting also of proteins such as Sec23 Sec13 and Sec31. The interaction of Sec24C with these proteins ensures the proper selection and packaging of cargo during vesicle budding therefore maintaining effective intracellular transport.

Pathways

Sec24C plays a role in the secretory pathway and is involved in the ER-to-Golgi transport. It functions in collaboration with other COPII components facilitating the packaging and movement of secretory proteins. Key proteins associated with this pathways include Sar1 and Sec23 which coordinate with Sec24C to regulate vesicle formation and cargo selection efficiently.

Disruptions in Sec24C function have been linked to neurological conditions such as Alzheimer's disease and certain forms of neurodegeneration. Altered Sec24C activity affects vesicle trafficking and protein processing interacting with proteins like APP (Amyloid precursor protein) which may lead to pathology. Understanding the role of Sec24C and its interactions could offer insights into therapeutic strategies for these diseases.
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Specifications

Form

Liquid

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General info

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 10214955, PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed : 20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed : 18843296).

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC24 subfamily.

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Product protocols

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Target data

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 10214955, PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed : 20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed : 18843296).
See full target information SEC24C
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