Recombinant Human Secretogranin 3 protein is a Human Full Length protein, in the 20 to 468 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S F P K P G G S Q D K S L H N R E L S A E R P L N E Q I A E A E E D K I K K T Y P P E N K P G Q S N Y S F V D N L N L L K A I T E K E K I E K E R Q S I R S S P L D N K L N V E D V D S T K N R K L I D D Y D S T K S G L D H K F Q D D P D G L H Q L D G T P L T A E D I V H K I A A R I Y E E N D R A V F D K I V S K L L N L G L I T E S Q A H T L E D E V A E V L Q K L I S K E A N N Y E E D P N K P T S W T E N Q A G K I P E K V T P M A A I Q D G L A K G E N D E T V S N T L T L T N G L E R R T K T Y S E D N F E E L Q Y F P N F Y A L L K S I D S E K E A K E K E T L I T I M K T L I D F V K M M V K Y G T I S P E E G V S Y L E N L D E M I A L Q T K N K L E K N A T D N I S K L F P A P S E K S H E E T D S T K E E A A K M E K E Y G S L K D S T K D D N S N P G G K T D E P K G K T E A Y L E A I R K N I E W L K K H D K K G N K E D Y D L S K M R D F I N K Q A D A Y V E K G I L D K E E A E A I K R I Y S S L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Alternative names
UNQ2502/PRO5990, SCG3, Secretogranin-3, Secretogranin III, SgIII
Recommended products
Recombinant Human Secretogranin 3 protein is a Human Full Length protein, in the 20 to 468 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q8WXD2-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S F P K P G G S Q D K S L H N R E L S A E R P L N E Q I A E A E E D K I K K T Y P P E N K P G Q S N Y S F V D N L N L L K A I T E K E K I E K E R Q S I R S S P L D N K L N V E D V D S T K N R K L I D D Y D S T K S G L D H K F Q D D P D G L H Q L D G T P L T A E D I V H K I A A R I Y E E N D R A V F D K I V S K L L N L G L I T E S Q A H T L E D E V A E V L Q K L I S K E A N N Y E E D P N K P T S W T E N Q A G K I P E K V T P M A A I Q D G L A K G E N D E T V S N T L T L T N G L E R R T K T Y S E D N F E E L Q Y F P N F Y A L L K S I D S E K E A K E K E T L I T I M K T L I D F V K M M V K Y G T I S P E E G V S Y L E N L D E M I A L Q T K N K L E K N A T D N I S K L F P A P S E K S H E E T D S T K E E A A K M E K E Y G S L K D S T K D D N S N P G G K T D E P K G K T E A Y L E A I R K N I E W L K K H D K K G N K E D Y D L S K M R D F I N K Q A D A Y V E K G I L D K E E A E A I K R I Y S S L
- Accession
- Q8WXD2
- Protein length
- Full Length
- Predicted molecular weight
- 53 kDa
- Amino acids
- 20 to 468
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab167866 was purified using conventional chromatography techniques.
General info
- Function
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
- Post-translational modifications
O-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Secretogranin 3 also known as SCG3 is a protein involved in the secretory pathway within cells. This protein belongs to the granin family weighing approximately 51 kDa. It is most commonly expressed in neuroendocrine cells and secretory granules throughout the body. Secretogranin 3 stores and transports peptide hormones and neuropeptides before their release into the extracellular space. As a secretory granule component it plays a role in the packaging and traffic of hormones and neuropeptides.
- Biological function summary
Secretogranin 3 helps regulate hormone secretion processes. It often works alongside other granin proteins within vesicles in neuroendocrine systems. Together with proteins like chromogranin A and chromogranin B it aids in sorting and packing peptide hormones and neuropeptides critical for cell communication. This coordination ensures that necessary signaling molecules are released appropriately to maintain normal physiological functions.
- Pathways
Secretogranin 3 operates within the secretory and neuroendocrine regulation pathways. It interacts with proteins involved in vesicle formation and transport such as synaptotagmins and syntaxins. These pathways are important in processes such as neurotransmitter release and hormone secretion. The interplay between Secretogranin 3 and these proteins supports the controlled secretion of hormones which is important for cell signaling and homeostasis.
- Associated diseases and disorders
Secretogranin 3's malfunction can associate with neuroendocrine tumors and metabolic disorders. Aberrations in SCG3 levels may correlate with altered hormone secretion leading to endocrine-related conditions. Disruption in its interaction with proteins like chromogranin A can contribute to the development or progression of certain tumors. Understanding how Secretogranin 3 and these proteins interact in disease contexts can aid in designing new therapeutic approaches.
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1 product image
SDS-PAGE - Recombinant Human Secretogranin 3 protein (ab167866)
15% SDS-PAGE analysis of 3µg ab167866.
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