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AB167866

Recombinant Human Secretogranin 3 protein (His tag N-Terminus)

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Recombinant Human Secretogranin 3 protein (His tag N-Terminus) is a Human Full Length protein, in the 20 to 468 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

UNQ2502/PRO5990, SCG3, Secretogranin-3, Secretogranin III, SgIII

1 Images
SDS-PAGE - Recombinant Human Secretogranin 3 protein (His tag N-Terminus) (AB167866)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Secretogranin 3 protein (His tag N-Terminus) (AB167866)

15% SDS-PAGE analysis of 3µg ab167866.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8WXD2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL","proteinLength":"Full Length","predictedMolecularWeight":"53 kDa","actualMolecularWeight":null,"aminoAcidEnd":468,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WXD2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Secretogranin 3 also known as SCG3 is a protein involved in the secretory pathway within cells. This protein belongs to the granin family weighing approximately 51 kDa. It is most commonly expressed in neuroendocrine cells and secretory granules throughout the body. Secretogranin 3 stores and transports peptide hormones and neuropeptides before their release into the extracellular space. As a secretory granule component it plays a role in the packaging and traffic of hormones and neuropeptides.
Biological function summary

Secretogranin 3 helps regulate hormone secretion processes. It often works alongside other granin proteins within vesicles in neuroendocrine systems. Together with proteins like chromogranin A and chromogranin B it aids in sorting and packing peptide hormones and neuropeptides critical for cell communication. This coordination ensures that necessary signaling molecules are released appropriately to maintain normal physiological functions.

Pathways

Secretogranin 3 operates within the secretory and neuroendocrine regulation pathways. It interacts with proteins involved in vesicle formation and transport such as synaptotagmins and syntaxins. These pathways are important in processes such as neurotransmitter release and hormone secretion. The interplay between Secretogranin 3 and these proteins supports the controlled secretion of hormones which is important for cell signaling and homeostasis.

Secretogranin 3's malfunction can associate with neuroendocrine tumors and metabolic disorders. Aberrations in SCG3 levels may correlate with altered hormone secretion leading to endocrine-related conditions. Disruption in its interaction with proteins like chromogranin A can contribute to the development or progression of certain tumors. Understanding how Secretogranin 3 and these proteins interact in disease contexts can aid in designing new therapeutic approaches.

Specifications

Form

Liquid

Additional notes

ab167866 was purified using conventional chromatography techniques.

General info

Function

Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed : 19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed : 29154827).

Post-translational modifications

O-glycosylated.

Product protocols

Target data

Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed : 19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed : 29154827).
See full target information SCG3

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