Recombinant Human Secretogranin V protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Secretogranin V also known as SgV or NESP55 is a member of the granin protein family involved in secretory pathways. This protein has a molecular mass of approximately 27 kDa. It localizes mainly in neuroendocrine tissues including the pituitary gland adrenal medulla and other components of the endocrine system. Secretogranin V is an acidic protein found within secretory vesicles where it plays a role in the storage and release of hormones and neurotransmitters.

Biological function summary

Secretogranin V participates in the regulation of neuropeptide and hormone secretion. It is a non-covalent member of large granular complexes within secretory granules. These complexes contribute to the sorting and packaging of bioactive peptides and proteins. In neuroendocrine cells secretogranin V aids in targeting secretory proteins to their proper vesicles ensuring effective storage and regulated exocytosis.

Pathways

Secretogranin V has significant roles in the endocrine and neuronal secretory pathways. It collaborates with other granins such as chromogranin A and chromogranin B which are implicated in the formation of secretory granules. The proteins in these pathways interact closely to manage the biosynthesis and exocytosis of hormones and neurotransmitter precursors. Pathways involving secretory storage are essential for maintaining cellular homeostasis and response to stimuli.

Secretogranin V modulates processes that may intersect with neuroendocrine tumors and stress-related disorders. Alterations in its expression or function can influence cell proliferation and hormone secretion contributing to the pathophysiology of these conditions. In the context of neuroendocrine tumors secretogranin V's interaction with synaptophysin and chromogranin proteins can affect tumor behavior and serve as a biomarker for diagnosis. In stress-related disorders its role in hormone regulation makes it relevant to research on hyperactivity of the adrenal and hypothalamic-pituitary-adrenal axis.