Recombinant Human SEMA4C/SEMAI protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEMA4C also known as SEMAI is a member of the semaphorin family which are proteins involved in cellular signaling. SEMA4C has a molecular mass of approximately 89 kDa and features in numerous cellular contexts. It is expressed in various tissues including the neural tissue muscle tissue and certain epithelial tissues. This expression suggests a diverse role in different cellular environments contributing to various physiological processes.

Biological function summary

SEMA4C plays a significant role in mediating cell-cell communication particularly in processes like axon guidance and cell migration. It acts as a ligand in binding to plexin receptors forming part of signaling complexes that regulate cellular dynamics. This protein can influence cytoskeletal reorganization which is also essential for connections between neurons and the development of the nervous system. SEMA4C is important for both developmental processes and responses in adults where its regulation impacts cellular behavior and function.

Pathways

SEMA4C modulates signaling cascades such as the MAPK pathway and the PI3K/AKT pathway. These pathways are critical in controlling growth and survival of cells. SEMA4C interacts with other proteins such as Plexin-B1 and Plexin-B2 signaling through these pathways and impacting neuronal development and immune response. It acts as a mediator between the extracellular environment and intracellular signaling mechanisms playing an important role in cellular responses to external stimuli.

SEMA4C is associated with cancer and neurodegenerative diseases. In cancer overexpression of SEMA4C can promote tumor progression and metastasis often linked with other proteins like Plexin-B1 in the tumor microenvironment. In the context of neurodegenerative diseases alterations or dysregulation of SEMA4C signaling can affect neuronal survival and connectivity and it might interact with proteins like tau contributing to disease progression. Understanding the function of SEMA4C in these conditions may provide avenues for therapeutic interventions.