Recombinant Human SEMA4G protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEMA4G also known as Semaphorin-4G functions mechanically as a signaling protein belonging to the semaphorin family. It plays a role in axon guidance and cellular interactions. The protein has a mass of approximately 84 kDa. SEMA4G is highly expressed in the nervous system with notable presence in regions like cerebellum and hippocampus suggesting roles in neural development and function.

Biological function summary

SEMA4G influences neuronal connectivity and cell signaling processes. It does not operate as part of a complex but interacts with receptors like plexins to influence cellular responses. SEMA4G helps in axonal pathfinding and synaptic organization playing key roles in the formation of neural circuits. These interactions suggest that SEMA4G assists in maintaining proper communication and organization within the nervous system.

Pathways

Researchers place SEMA4G within axon guidance and semaphorin-plexin signaling pathways. Within these SEMA4G interacts with protein partners such as Plexin-B1 which helps mediate downstream signaling events essential for neurite outgrowth and retraction. These signaling events ensure proper neural circuit formation and are important for healthy neural function.

Altered SEMA4G expression or function links to neurological disorders including autism spectrum disorders. Aberrant semaphorin signaling can disrupt neuronal connectivity contributing to developmental issues. In neurodegenerative conditions like Alzheimer's disease altered SEMA4G levels associate with disrupted synaptic organization. Connections to proteins like Plexin-B1 and their altered signaling can contribute to these disease states indicating the importance of precise SEMA4G function in maintaining neural health.