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AB163586

Recombinant Human Sema6A protein (GST tag N-Terminus)

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Recombinant Human Sema6A protein (GST tag N-Terminus) is a Human Fragment protein, in the 21 to 120 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1368, SEMAQ, SEMA6A, Semaphorin-6A, Semaphorin VIA, Semaphorin-6A-1, Sema VIA, SEMA6A-1

1 Images
SDS-PAGE - Recombinant Human Sema6A protein (GST tag N-Terminus) (AB163586)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Sema6A protein (GST tag N-Terminus) (AB163586)

ab163586 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9H2E6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"PEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNF","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":120,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H2E6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Semaphorin 6A also known as Sema6A is a transmembrane protein that plays a significant role in axon guidance and cell signaling. It has a mass of approximately 95 kDa and is a member of the semaphorin protein family. Sema6A is expressed mainly in the nervous system but also found in other tissues like the heart and kidney. In neuronal cells it interacts with plexin receptors to guide axonal pathways influencing the growth cone dynamics during neural development.
Biological function summary

Sema6A plays a role in cellular navigation during neural development. It functions as a signaling cue that aids in cell positioning by influencing the structure and orientation of the cellular cytoskeleton. Although not part of a large protein complex itself Sema6A can interact with plexins to modulate other cellular pathways. The interactions help manage axonal growth and directionality essential for proper neural circuit formation.

Pathways

Sema6A significantly influences the axon guidance and neural crest cell migration pathways. In these pathways it interacts with proteins such as plexin-A4 which play key roles in transducing semaphorin signals to the cytoskeleton. By guiding axonal direction Sema6A integrates into neural development processes as well as affecting the migration of neurons and their interaction within different tissues.

Sema6A is associated with neurodevelopmental disorders and cancer metastasis. Mutations or dysregulation within Sema6A signaling can contribute to conditions such as autism spectrum disorder where it may affect neural connectivity. In cancer irregular expression of Sema6A might influence tumor progression and metastasis by interacting with plexin receptors changing cell adhesion properties and impacting cell migration.
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Specifications

Form

Liquid

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General info

Function

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.

Sequence similarities

Belongs to the semaphorin family.

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Product protocols

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Target data

Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
See full target information SEMA6A
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