Recombinant Human Semaphorin 4D/CD100 protein is a Human Fragment protein, in the 22 to 734 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
M A F A P I P R I T W E H R E V H L V Q F H E P D I Y N Y S A L L L S E D K D T L Y I G A R E A V F A V N A L N I S E K Q H E V Y W K V S E D K K A K C A E K G K S K Q T E C L N Y I R V L Q P L S A T S L Y V C G T N A F Q P A C D H L N L T S F K F L G K N E D G K G R C P F D P A H S Y T S V M V D G E L Y S G T S Y N F L G S E P I I S R N S S H S P L R T E Y A I P W L N E P S F V F A D V I R K S P D S P D G E D D R V Y F F F T E V S V E Y E F V F R V L I P R I A R V C K G D Q G G L R T L Q K K W T S F L K A R L I C S R P D S G L V F N V L R D V F V L R S P G L K V P V F Y A L F T P Q L N N V G L S A V C A Y N L S T A E E V F S H G K Y M Q S T T V E Q S H T K W V R Y N G P V P K P R P G A C I D S E A R A A N Y T S S L N L P D K T L Q F V K D H P L M D D S V T P I D N R P R L I K K D V N Y T Q I V V D R T Q A L D G T V Y D V M F V S T D R G A L H K A I S L E H A V H I I E E T Q L F Q D F E P V Q T L L L S S K K G N R F V Y A G S N S G V V Q A P L A F C G K H G T C E D C V L A R D P Y C A W S P P T A T C V A L H Q T E S P S R G L I Q E M S G D A S V C P D K S K G S Y R Q H F F K H G G T A E L K C S Q K S N L A R V F W K F Q N D V L K A E S P K Y G L M G R K N L L I F N L S E G D S G V Y Q C L S E E R V K N K T V F Q V V A K H V L E V K V V P K P V V A P T L S V V Q T E G S R I A T K V L V A S T Q G S S P P T P A V Q A T S S G A I T L P P K P A P T G T S C E P K I V I N T V P Q L H S E K T M Y L K S S D N R V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
CD100, C9orf164, SEMAJ, SEMA4D, Semaphorin-4D, A8, BB18, GR3
Recombinant Human Semaphorin 4D/CD100 protein is a Human Fragment protein, in the 22 to 734 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 7.4
Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
Belongs to the semaphorin family.
This product was previously labelled as Semaphorin 4D
Semaphorin 4D also known as CD100 is a transmembrane protein that plays important roles in cellular signaling. It belongs to the semaphorin protein family known for their role in axonal guidance. CD100 has a molecular mass of approximately 150 kDa. This protein expresses mainly in the immune system including T cells and B cells but can also be found in certain neurons and endothelial cells. It can exist in both a membrane-bound form and a soluble form which arise from proteolytic cleavage.
CD100 influences various cellular functions by interacting with multiple receptors such as Plexin-B1 and CD72 as part of a larger signaling complex. It contributes to immune response regulation by promoting T-cell activation and B-cell aggregation which are essential for adaptive immunity. In the nervous system it guides neural development including axon growth and synaptic plasticity. CD100's interaction with Plexin-B1 plays a significant role in these developmental processes often affecting cell morphology and movement.
Semaphorin 4D is involved in both immune and neural signaling pathways. In the immune system it influences the PI3K-Akt signaling pathway which impacts cell survival and immune cell activation. It associates with pathways involving Plexin-B1 and RhoA to regulate cytoskeletal dynamics affecting cell motility and growth. Additionally CD100's role in neural pathways intersects with proteins like neuropilin-1 influencing semaphorin-mediated signaling essential for neural connectivity.
Semaphorin 4D has links to cancer and autoimmune diseases. High expression levels of CD100 are observed in several tumor types where it might promote tumor growth and metastasis through its signaling pathways. In autoimmune conditions like multiple sclerosis CD100 affects immune cell interactions and can exacerbate inflammatory responses. Its involvement with proteins such as CD72 and Plexin-B1 in these conditions highlights its contribution to pathogenesis and potential as a therapeutic target.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com