Recombinant Human SEMG2 protein (His Tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Semenogelin II also known as SGII is a protein that plays a significant role in human reproduction. It is a major component of semen and weighs approximately 50 kDa. This protein is primarily expressed in the seminal vesicles. SGII is closely related to Semenogelin I (SGI) and shares a high degree of sequence homology. The presence of these proteins is important to semen coagulation affecting viscosity and ultimately fertility.

Biological function summary

Semenogelin II contributes to the formation of the seminal coagulum which provides an essential function in immobilizing sperm temporarily after ejaculation. This protein interacts within a complex network involving prostate-specific antigen (PSA) which partially degrades SGII to liquefy the coagulum allowing sperm motility and facilitating fertilization. The activity of SGII in semen coagulation and subsequent liquefaction demonstrates its impact on reproductive success.

Pathways

Semenogelin II is integral to the reproductive pathway involving sperm maturation and fertilization. The effort of PSA to degrade SGII and its counterpart Semenogelin I is central to the regulation of semen liquefaction. This interaction is important to the seminal plasma proteolysis pathway. Proteins such as matrix metalloproteinases are also part of this pathway although they have a distinct and less direct relationship with SGII.

Abnormalities in the function or expression of Semenogelin II have implications for infertility. Altered SGII levels or dysfunction can impact semen coagulation which may lead to reduced sperm motility and decreased chances of successful fertilization. Additionally SGII is studied for its potential involvement in prostate cancer since its regulation by PSA suggests a connection. Understanding SGII's role in these contexts might provide insights into both reproductive health and prostate disease management.