Recombinant human SENP2 protein (Active)
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Recombinant human SENP2 protein (Active) is a Human Fragment protein, in the 360 to 589 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
KIAA1331, SENP2, Sentrin-specific protease 2, Axam2, SMT3-specific isopeptidase 2, Sentrin/SUMO-specific protease SENP2, Smt3ip2
- FuncS
Supplier Data
Functional Studies - Recombinant human SENP2 protein (Active) (AB268954)
The specific activity of ab268954 was ≥3351 nmol/min/mg in a deubiquitinase assay using recombinant human SUMO1-based proluciferin protein as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human SENP2 protein (Active) (AB268954)
SDS-PAGE analysis of ab268954.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SUMO E3 ligase complexes often include SENP2 as an integral part. It modulates various signaling pathways by targeting transcription factors and other proteins involved in cellular stress response cell division and apoptosis. Through de-sumoylation SENP2 influences the activity of proteins by altering their transcriptional potency nuclear transport or protein degradation rates. SENP2's activity ensures appropriate cellular responses to environmental cues and maintains proper cellular homeostasis by balancing protein modifications.
Pathways
SUMO-related mechanisms like nucleocytoplasmic transport and DNA repair involve SENP2. In these pathways SENP2 interacts with proteins like RanBP2 and PML contributing to cell cycle regulation and maintaining genomic stability. In the hypoxia response pathway SENP2's influence is important for modulating hypoxia-inducible factors (HIFs). These interactions illustrate SENP2’s regulatory roles in adapting cellular function in response to stress and changes in the cellular environment.
Specifications
Form
Liquid
General info
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed : 11896061, PubMed : 12192048, PubMed : 15296745, PubMed : 20194620, PubMed : 21965678). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed : 15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed : 15296745, PubMed : 20194620, PubMed : 21965678). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed : 21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed : 20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Sequence similarities
Belongs to the peptidase C48 family.
Post-translational modifications
Polyubiquitinated; which leads to proteasomal degradation.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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