Recombinant Human SENP8 protein
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(1 Publication)
Recombinant Human SENP8 protein is a Human Full Length protein, in the 1 to 212 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
DEN1, NEDP1, PRSC2, FKSG8, SENP8, Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Sentrin/SUMO-specific protease SENP8
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human SENP8 protein (AB109837)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SENP8 plays an important role in regulating neddylation influencing protein stability activity and localization. SENP8 operates independently rather than as a part of any larger protein complex. Its activity is important in cell cycle regulation DNA replication and repair. By removing NEDD8 from target proteins SENP8 controls the degradation of certain proteins impacting cellular processes.
Pathways
SENP8 links tightly with the neddylation and ubiquitin-proteasome pathways. These pathways govern protein turnover and degradation impacting cell cycle control and apoptosis. SENP8 influences proteins such as cullins which are core components of the SCF ubiquitin ligase complex. This relationship highlights SENP8's critical role in cellular protein homeostasis and regulation through these pathways.
Specifications
Form
Liquid
Additional notes
No detergents such as urea, Triton or Tween were used to purify the proteins. Purified by using anion exchange chromatography (DEAE sepharose resin) and gel filtration chromatography (Sephacryl S 200) with 20mM Tris pH 7.5, 2mM EDTA.
General info
Function
Protease that catalyzes two essential functions in the NEDD8 pathway : processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Sequence similarities
Belongs to the peptidase C48 family.
Target data
Publications (1)
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The EMBO journal 24:1341-51 PubMed15775960
2005
Applications
Unspecified application
Species
Unspecified reactive species
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