JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB153408

Recombinant Human Septin 11 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Septin 11 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 429 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SEPT11, SEPTIN11, Septin-11

1 Images
SDS-PAGE - Recombinant Human Septin 11 protein (GST tag N-Terminus) (AB153408)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Septin 11 protein (GST tag N-Terminus) (AB153408)

ab153408 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NVA2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

  • 5
  • 1
Proteins & Peptides

AB132942

Recombinant Human Ezrin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Ezrin protein (GST tag N-Terminus) (AB132942)

  • 0
  • 0
Primary Antibodies

AB183529

Anti-Septin 11 antibody

Immunoprecipitation - Anti-Septin 11 antibody (AB183529)

  • 0
  • 0
Proteins & Peptides

AB98249

Recombinant Human Ogg1 protein (His tag N-Terminus)

Western blot - Recombinant Human Ogg1 protein (His tag N-Terminus) (AB98249)

  • 1
  • 1
Proteins & Peptides

AB112321

Recombinant Human MEIS1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MEIS1 protein (GST tag N-Terminus) (AB112321)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":429,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NVA2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Septin 11 also known as SEPT11 functions as a GTPase involved in the formation of filamentous structures. This protein has a molecular mass of approximately 49 kDa. It is expressed in a wide range of tissues but most abundantly in the brain. Septin 11 belongs to the septin family which consists of cytoskeletal proteins important for cellular processes like cytokinesis and vesicle trafficking.
Biological function summary

The protein plays a role in cellular structure and integrity forming a complex with other septins to maintain cellular shape and facilitate mitotic processes. Septin 11 participates in organizing the actin cytoskeleton which affects cell division and movement. Its interaction with microtubules also suggests roles in intracellular transport and neural communication.

Pathways

Septin 11 is involved in actin and microtubule dynamics. It interacts with pathways that govern cellular cycle regulation and signal transduction. Related proteins like Septin 2 and Septin 9 play interactive roles in these pathways contributing to the complex orchestration of cellular organization and division. Their coordinated function ensures proper cell cycle progression and developmental processes.

Abnormalities in Septin 11 expression or function link to neurodegenerative diseases and cancer. Dysregulation can contribute to conditions such as Alzheimer's disease potentially through its interactions with tau proteins. Additionally altered Septin 11 expression associates with tumorigenesis as seen in some forms of leukemia where it interacts with proteins like BCR-ABL. Understanding Septin 11’s role in these diseases aids in the development of targeted therapeutic strategies.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Subcellular localisation

Cytoskeleton

style
left-column

Product protocols

style
left-column

Target data

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
See full target information SEPTIN11
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com