Recombinant Human Septin 2 protein is a Human Full Length protein, in the 1 to 361 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M S K Q Q P T Q F I N P E T P G Y V G F A N L P N Q V H R K S V K K G F E F T L M V V G E S G L G K S T L I N S L F L T D L Y P E R V I S G A A E K I E R T V Q I E A S T V E I E E R G V K L R L T V V D T P G Y G D A I N C R D C F K T I I S Y I D E Q F E R Y L H D E S G L N R R H I I D N R V H C C F Y F I S P F G H G L K P L D V A F M K A I H N K V N I V P V I A K A D T L T L K E R E R L K K R I L D E I E E H N I K I Y H L P D A E S D E D E D F K E Q T R L L K A S I P F S V V G S N Q L I E A K G K K V R G R L Y P W G V V E V E N P E H N D F L K L R T M L I T H M Q D L Q E V T Q D L H Y E N F R S E R L K R G G R K V E N E D M N K D Q I L L E K E A E L R R M Q E M I A R M Q A Q M Q M Q M Q G G D G D G G A L G H H V
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
DIFF6, KIAA0158, NEDD5, SEPT2, SEPT2, NEDD5, KIAA0158, DIFF6, SEPTIN2, Septin-2, Neural precursor cell expressed developmentally down-regulated protein 5, NEDD-5
Recombinant Human Septin 2 protein is a Human Full Length protein, in the 1 to 361 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
M G S S H H H H H H S S G L V P R G S H M S K Q Q P T Q F I N P E T P G Y V G F A N L P N Q V H R K S V K K G F E F T L M V V G E S G L G K S T L I N S L F L T D L Y P E R V I S G A A E K I E R T V Q I E A S T V E I E E R G V K L R L T V V D T P G Y G D A I N C R D C F K T I I S Y I D E Q F E R Y L H D E S G L N R R H I I D N R V H C C F Y F I S P F G H G L K P L D V A F M K A I H N K V N I V P V I A K A D T L T L K E R E R L K K R I L D E I E E H N I K I Y H L P D A E S D E D E D F K E Q T R L L K A S I P F S V V G S N Q L I E A K G K K V R G R L Y P W G V V E V E N P E H N D F L K L R T M L I T H M Q D L Q E V T Q D L H Y E N F R S E R L K R G G R K V E N E D M N K D Q I L L E K E A E L R R M Q E M I A R M Q A Q M Q M Q M Q G G D G D G G A L G H H V
Full Length
43.6 kDa
1 to 361
Recombinant
His tag N-Terminus
Liquid
ab99296 is purified using conventional chromatography techniques.
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cytoskeleton, Spindle
Blue Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
Septin 2 also known as septin-2 or SEPT2 is a GTP-binding protein with a molecular mass of approximately 41 kDa. It functions mechanically as a major component of the cytoskeletal structure playing an essential role in cellular organization and division. Septin 2 is expressed across various human tissues and cell types indicative of its fundamental role in maintaining cellular integrity. It participates in organizing the actin cytoskeleton and is necessary for cytokinesis.
Septin 2 integrates into a filamentous network interacting closely with other septins to form hetero-oligomeric complexes essential for cellular dynamics. The protein contributes to the formation of diffusion barriers within membranes facilitating compartmentalization in the cells. As a structural element it supports cellular morphogenesis polarity and vesicle trafficking. The collaborative action within septin complexes ensures effective cell cycle progression and signal transduction.
Septin 2 plays a part in key cellular pathways including the cell cycle and apoptosis pathways. The interaction of Septin 2 with proteins like Cdc42 and Rac1 impacts signaling cascades pivotal for actin cytoskeleton organization. The septin complex is important for modulating these pathways as it influences cellular responses to environmental cues. Through these pathways Septin 2 contributes to critical processes such as mitotic spindle positioning and stability.
Altered expression or function of Septin 2 is linked to cancer including gliomas where septin dysregulation affects tumor growth and metastasis. Additionally the protein has connections to neurodegenerative disorders such as Alzheimer's disease. Within these contexts proteins like Cdc42 and Rac1 further influence Septin 2's role modulating disease progression through pathways involved in cell migration and proliferation. Understanding Septin 2 in these disorders provides insight into potential therapeutic targets for intervention.
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15% SDS-PAGE showing ab99296 (3μg).
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