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AB202152

Recombinant Human Septin 3 protein

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Recombinant Human Septin 3 protein is a Human Full Length protein, in the 1 to 358 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SEP3, SEPT3, SEPTIN3, Neuronal-specific septin-3

1 Images
SDS-PAGE - Recombinant Human Septin 3 protein (AB202152)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Septin 3 protein (AB202152)

15% SDS-PAGE analysis of ab202152 (3 μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9UH03

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE","proteinLength":"Full Length","predictedMolecularWeight":"43.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":358,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UH03","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Septin 3 sometimes referred to as SEPT3 is a cytoskeletal protein known to play a role in cell division and compartmentalization. It belongs to the septin family of GTP-binding proteins which are characterized by their filament-forming abilities. SEPT3 has a molecular mass of approximately 40.3 kDa. Expression of SEPT3 occurs mainly in the brain particularly in neurons indicating its importance in nervous system functions.
Biological function summary

SEPT3 is involved in maintaining cellular structure and facilitating membrane dynamics. It functions as part of a larger complex that is essential for proper neuronal function. SEPT3 interacts with other septins to form hetero-oligomeric filaments which contribute to processes such as cytokinesis vesicle trafficking and dendritic spine morphology. This protein complex provides structural support and functional regulation within cells impacting areas like synaptic plasticity.

Pathways

SEPT3 integrates into key mechanisms that regulate neuron development and signal transmission. It participates in the actin and microtubule dynamics pathways directly affecting cellular architecture and transport processes. SEPT3 associates with proteins like SEPT5 and SEPT7 which coordinate cytoskeletal arrangements and are integral to maintaining proper cellular activities and responses.

SEPT3 has a notable presence in studies related to neurodegenerative diseases and mood disorders. Dysfunction or dysregulation of SEPT3 is linked to conditions like Alzheimer's disease and schizophrenia. SEPT3 associates with proteins such as tau and synapsin which are known to be altered in these diseases. Understanding the role of SEPT3 in these conditions could provide insights into potential therapeutic avenues.
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Specifications

Form

Liquid

Additional notes

ab202152 was purified using conventional chromatography techniques.

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General info

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Post-translational modifications

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).

Subcellular localisation

Cytoskeleton

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
See full target information SEPTIN3
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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