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AB153267

Recombinant Human SERBP1 protein (GST tag N-Terminus)

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Recombinant Human SERBP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

PAIRBP1, CGI-55, SERBP1, SERPINE1 mRNA-binding protein 1, PAI1 RNA-binding protein 1, Plasminogen activator inhibitor 1 RNA-binding protein, PAI-RBP1

1 Images
SDS-PAGE - Recombinant Human SERBP1 protein (GST tag N-Terminus) (AB153267)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SERBP1 protein (GST tag N-Terminus) (AB153267)

ab153267 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8NC51

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB159577

Recombinant Human SREBP1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human SREBP1 protein (GST tag N-Terminus) (AB159577)

  • 0
  • 0
Primary Antibodies

AB32028

Anti-mTOR antibody [Y391]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-mTOR antibody [Y391] (AB32028)

  • 3
  • 4
Primary Antibodies

AB22759

Anti-Fatty Acid Synthase antibody

KO Validated

Western blot - Anti-Fatty Acid Synthase antibody (AB22759)

  • 5
  • 14
Primary Antibodies

AB52641

Anti-STK3/MST-2 antibody [EP1466Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK3/MST-2 antibody [EP1466Y] (AB52641)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGCGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NC51","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERBP1 also known as SCR3 is a protein weighing approximately 46 kDa. This protein interacts with specific mRNA sequences acting as a binding protein that influences mRNA stability and modulates the translation process. SERBP1 is widely expressed in various tissues notably in the liver and placenta where it plays a role in cellular activities related to protein synthesis.
Biological function summary

Activities performed by SERBP1 involve regulation of mRNA turnover and translation impacting critical cellular functions. SERBP1 forms part of the ribonucleoprotein complexes which bind to mRNA and stabilize it therefore influencing gene expression. Through these interactions it has a significant impact on the control of translation processes within the cell alongside other regulatory proteins.

Pathways

SERBP1 participates in mRNA surveillance and regulation pathways. This protein interacts with key translation pathways contributing to processes that ensure only properly processed mRNA is translated into proteins. SERBP1's role in these pathways may involve interactions with proteins like eIF4E which also plays a part in translation initiation thereby maintaining cellular homeostasis and efficiency in protein production.

Changes in SERBP1 expression or function can relate to cancer and liver disease. In such conditions aberrant regulation of mRNA stability may occur leading to dysregulated protein synthesis that contributes to pathogenesis. SERBP1 is connected to proteins such as c-Myc in cancer where it may play a role in the overexpression of oncogenes linking these pathway interactions to disease states.
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Specifications

Form

Liquid

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General info

Function

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed : 36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability : binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed : 11001948). Seems to play a role in PML-nuclear bodies formation (PubMed : 28695742).

Sequence similarities

Belongs to the SERBP1-HABP4 family.

Post-translational modifications

Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed : 36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability : binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed : 11001948). Seems to play a role in PML-nuclear bodies formation (PubMed : 28695742).
See full target information SERBP1
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Product promise

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