Recombinant Human SERF2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERF2 also known as Small EDRK-Rich Factor 2 is a protein with a molecular mass of about 13 kDa. Mechanically SERF2 interacts with components in the cell that influence protein aggregation and stability. It has a significant expression in a variety of tissues including the brain and liver and exhibits nuclear localization which suggests involvement within important cellular functions.

Biological function summary

This protein facilitates processes that ensure proper protein folding and degradation reducing the chance of aggregation. SERF2 functions independently and does not form a well-characterized complex. Its influence on protein dynamics plays an important role in maintaining cellular protein homeostasis. It acts by modulating activities that prevent the accumulation of improperly folded protein thereby conferring cellular stress resistance.

Pathways

SERF2 impacts several via integration into protein quality control mechanisms. Notably it involves itself in the ubiquitin-proteasome system and the heat shock response pathways. SERF2 works alongside proteins such as ubiquitin ligases and heat shock proteins augmenting their role in recognizing and refolding injured proteins or targeting them for degradation. This coordination is vital for reducing cellular stress responses.

SERF2 connects to neurodegenerative diseases like Alzheimer's and Parkinson's where protein aggregation is an important feature. Its action against protein accumulation is beneficial in mitigating such pathologies. In Alzheimer's disease SERF2 can interact with tau protein while in Parkinson's disease it may have links with alpha-synuclein. Understanding SERF2's actions in these contexts offers insight into potential therapeutic strategies.