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AB163575

Recombinant Human SERINC1 protein

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Recombinant Human SERINC1 protein is a Human Full Length protein, in the 1 to 453 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1253, TDE1L, TDE2, UNQ396/PRO732, SERINC1, Serine incorporator 1, Tumor differentially expressed protein 1-like, Tumor differentially expressed protein 2

1 Images
SDS-PAGE - Recombinant Human SERINC1 protein (AB163575)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human SERINC1 protein (AB163575)

ab163575 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9NRX5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":453,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NRX5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERINC1 also known as Serine Incorporator 1 is a membrane protein involved in the incorporation of serine into lipids. It has a molecular mass of approximately 53 kDa. Scientists have identified SERINC1 as highly expressed in several tissues including the brain testis and liver. The protein localizes largely at the plasma membrane and participates actively in lipid biosynthesis.
Biological function summary

SERINC1 modulates the synthesis of phosphatidylserine and sphingolipids which are critical for cellular functions. It acts as part of a larger complex playing a role in the folding and trafficking of proteins to the membrane. SERINC1's activity influences membrane-related processes which include vesicle trafficking and cell signaling. In particular the protein impacts cellular processes through the regulation of membrane composition.

Pathways

Researchers have placed SERINC1 within the lipid metabolism and serine biosynthesis pathways. SERINC1 regulates the distribution of serine into pathways necessary for lipid and nucleotide synthesis. Other proteins related to these pathways include CDP-diacylglycerol—serine O-phosphate phosphatidyltransferase 1 which is key in the phosphatidylserine biosynthetic process. The interaction between these proteins ensures proper cellular lipid composition and function.

Studies have linked SERINC1 to neurological and metabolic conditions. Dysregulation of SERINC1 is observed in some cases of schizophrenia suggesting its involvement in neurological pathways. Furthermore disturbances in lipid metabolism such as those found in metabolic syndrome may involve altered SERINC1 function. Its relationship with proteins like phosphatidylserine decarboxylase central to the production of phosphatidylethanolamine highlights its relevance in disease contexts where lipid imbalances are pronounced.
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Specifications

Form

Liquid

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General info

Function

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Sequence similarities

Belongs to the TDE1 family.

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Product protocols

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Target data

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
See full target information SERINC1
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Primary Antibodies

AB236894

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