Recombinant Human Serine racemase protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
M G S S H H H H H H S S G L V P R G S H M G S H M C A Q Y C I S F A D V E K A H I N I R D S I H L T P V L T S S I L N Q L T G R N L F F K C E L F Q K T G S F K I R G A L N A V R S L V P D A L E R K P K A V V T H S S G N H G Q A L T Y A A K L E G I P A Y I V V P Q T A P D C K K L A I Q A Y G A S I V Y C E P S D E S R E N V A K R V T E E T E G I M V H P N Q E P A V I A G Q G T I A L E V L N Q V P L V D A L V V P V G G G G M L A G I A I T V K A L K P S V K V Y A A E P S N A D D C Y Q S K L K G K L M P N L Y P P E T I A D G V K S S I G L N T W P I I R D L V D D I F T V T E D E I K C A T Q L V W E R M K L L I E P T A G V G V A A V L S Q H F Q T V S P E V K N I C I V L S G G N V D L T S S I T W V K Q A E R P A S Y Q S V S V
Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase, SRR
Recombinant Human Serine racemase protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
ab116196 was purified using conventional chromatography.
Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
Belongs to the serine/threonine dehydratase family.
S-nitrosylated, leading to decrease the enzyme activity.
Serine racemase also known as SRR is an enzyme involved in the conversion of L-serine to D-serine a process that helps regulate neural signaling. The enzyme has a molecular mass of approximately 37 kDa and is expressed highly in the brain specifically in regions such as the hippocampus and cortex. It utilizes pyridoxal phosphate (PLP) as a cofactor to catalyze the racemization and in certain conditions it also exhibits dehydratase activity converting serine to pyruvate and ammonia.
Serine racemase plays an important role in the central nervous system. D-serine the product of its action serves as a co-agonist with glutamate at the NMDA receptor which is important for synaptic plasticity and memory formation. Serine racemase also associates with proteins like PICK1 and Golga3 affecting its localization and activity within cells. The regulation of D-serine levels impacts neurotransmission and neuron viability.
Serine racemase is integral to the serine metabolism and NMDA receptor signaling pathways. It interacts with the enzyme glycine decarboxylase which is involved in glycine metabolism demonstrating its role in amino acid regulation. Its activity connects to the glutamatergic neurotransmission pathway influencing calcium influx and downstream signaling cascades that are essential for long-term potentiation and neuroplasticity.
Alterations in serine racemase activity or expression have been linked to conditions such as schizophrenia and Alzheimer's disease. In schizophrenia disruptions in D-serine levels possibly through interactions with proteins like NMDA receptor and D-amino acid oxidase can lead to impaired NMDA receptor function. In Alzheimer's disease abnormal D-serine metabolism is associated with neurodegeneration often involving proteins like amyloid-beta which exacerbates disease pathology.
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15% SDS-PAGE analysis of 3 µg ab116196.
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