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Recombinant Human Serine racemase protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human Serine racemase protein (AB116196), expandable thumbnail

Key facts

Purity
>85% SDS-PAGE
Expression system
Escherichia coli
Tags
His tag N-Terminus
Applications
SDS-PAGE, MS
Biologically active
No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S H M C A Q Y C I S F A D V E K A H I N I R D S I H L T P V L T S S I L N Q L T G R N L F F K C E L F Q K T G S F K I R G A L N A V R S L V P D A L E R K P K A V V T H S S G N H G Q A L T Y A A K L E G I P A Y I V V P Q T A P D C K K L A I Q A Y G A S I V Y C E P S D E S R E N V A K R V T E E T E G I M V H P N Q E P A V I A G Q G T I A L E V L N Q V P L V D A L V V P V G G G G M L A G I A I T V K A L K P S V K V Y A A E P S N A D D C Y Q S K L K G K L M P N L Y P P E T I A D G V K S S I G L N T W P I I R D L V D D I F T V T E D E I K C A T Q L V W E R M K L L I E P T A G V G V A A V L S Q H F Q T V S P E V K N I C I V L S G G N V D L T S S I T W V K Q A E R P A S Y Q S V S V

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
MS
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Function

Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).

Alternative names

Recommended products

Recombinant Human Serine racemase protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.

Key facts

Purity
>85% SDS-PAGE
Expression system
Escherichia coli
Applications
SDS-PAGE, MS
Accession
Q9GZT4-1
Animal free
No
Species
Human
Concentration
Loading...
Storage buffer

pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S H M C A Q Y C I S F A D V E K A H I N I R D S I H L T P V L T S S I L N Q L T G R N L F F K C E L F Q K T G S F K I R G A L N A V R S L V P D A L E R K P K A V V T H S S G N H G Q A L T Y A A K L E G I P A Y I V V P Q T A P D C K K L A I Q A Y G A S I V Y C E P S D E S R E N V A K R V T E E T E G I M V H P N Q E P A V I A G Q G T I A L E V L N Q V P L V D A L V V P V G G G G M L A G I A I T V K A L K P S V K V Y A A E P S N A D D C Y Q S K L K G K L M P N L Y P P E T I A D G V K S S I G L N T W P I I R D L V D D I F T V T E D E I K C A T Q L V W E R M K L L I E P T A G V G V A A V L S Q H F Q T V S P E V K N I C I V L S G G N V D L T S S I T W V K Q A E R P A S Y Q S V S V
Accession
Q9GZT4
Protein length
Full Length
Predicted molecular weight
39.1 kDa
Amino acids
1 to 340
Nature
Recombinant
Tags
His tag N-Terminus

Specifications

Form
Liquid
Additional notes

ab116196 was purified using conventional chromatography.

General info

Function

Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Post-translational modifications

S-nitrosylated, leading to decrease the enzyme activity.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Serine racemase also known as SRR is an enzyme involved in the conversion of L-serine to D-serine a process that helps regulate neural signaling. The enzyme has a molecular mass of approximately 37 kDa and is expressed highly in the brain specifically in regions such as the hippocampus and cortex. It utilizes pyridoxal phosphate (PLP) as a cofactor to catalyze the racemization and in certain conditions it also exhibits dehydratase activity converting serine to pyruvate and ammonia.

Biological function summary

Serine racemase plays an important role in the central nervous system. D-serine the product of its action serves as a co-agonist with glutamate at the NMDA receptor which is important for synaptic plasticity and memory formation. Serine racemase also associates with proteins like PICK1 and Golga3 affecting its localization and activity within cells. The regulation of D-serine levels impacts neurotransmission and neuron viability.

Pathways

Serine racemase is integral to the serine metabolism and NMDA receptor signaling pathways. It interacts with the enzyme glycine decarboxylase which is involved in glycine metabolism demonstrating its role in amino acid regulation. Its activity connects to the glutamatergic neurotransmission pathway influencing calcium influx and downstream signaling cascades that are essential for long-term potentiation and neuroplasticity.

Associated diseases and disorders

Alterations in serine racemase activity or expression have been linked to conditions such as schizophrenia and Alzheimer's disease. In schizophrenia disruptions in D-serine levels possibly through interactions with proteins like NMDA receptor and D-amino acid oxidase can lead to impaired NMDA receptor function. In Alzheimer's disease abnormal D-serine metabolism is associated with neurodegeneration often involving proteins like amyloid-beta which exacerbates disease pathology.

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1 product image

  • SDS-PAGE - Recombinant Human Serine racemase protein (ab116196), expandable thumbnail

    SDS-PAGE - Recombinant Human Serine racemase protein (ab116196)

    15% SDS-PAGE analysis of 3 µg ab116196.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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