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AB152010

Recombinant Human SerpinB6/CAP protein

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Recombinant Human SerpinB6/CAP protein is a Human Full Length protein, in the 1 to 376 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

PI6, PTI, SERPINB6, Serpin B6, Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, CAP, PI-6

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Trx tag N-Terminus 6x His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P35237

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Complementary Products

Primary Antibodies

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Proteins & Peptides

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Primary Antibodies

AB133612

Anti-Osteocalcin antibody [EPR3690]

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Western blot - Anti-Osteocalcin antibody [EPR3690] (AB133612)

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Primary Antibodies

AB214821

Anti-BMP2 antibody [EPR20807]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-BMP2 antibody [EPR20807] (AB214821)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Product previously known as Recombinant Human SerpinB6 protein.
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Sequence info

[{"sequence":"MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP","proteinLength":"Full Length","predictedMolecularWeight":"42.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":376,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P35237","tags":[{"tag":"Trx","terminus":"N-Terminus"},{"tag":"6x His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SerpinB6 also known as CAP or cytoplasmic antiproteinase functions as a serine protease inhibitor. It weighs approximately 42 kDa. This protein is specific in inhibiting intracellular serine proteases regulating proteolytic processes. SerpinB6 expresses widely across tissues with high levels noted in the extravascular regions such as kidney placenta liver and leukocytes. It serves a cellular protective role by preventing inappropriate proteolysis that could damage cells.
Biological function summary

SerpinB6 plays an important role in protecting cells from protease-dependent damage particularly in stress conditions like heat shock. It operates independently and does not integrate into multiprotein complexes sticking to its role of solo protease control. This protein helps in maintaining cellular integrity safeguarding vital intra-cellular components from degradation by serine proteases particularly during stress responses which affect survival of certain cell types.

Pathways

SerpinB6 contributes significantly to regulating pathways involved in cellular stress response and inflammation. Specifically it engages in pathways such as the regulation of immune response and apoptosis acting alongside other serine protease inhibitors. SerpinB6 interacts with proteins like cathepsin G and elastase which are components of innate immunity and apoptosis pathways.

Dysfunction of SerpinB6 associates with sensorineural hearing loss and certain immune disorders. Hearing loss links to its incapability to inhibit proteases effectively in inner ear cells leading to cell death. In immune disorders inadequate regulation of proteolytic activity can cause exaggerated inflammation. SerpinB6's interaction with proteins such as cathepsin G positions it as a potential therapeutic target for modulating immune responses and preserving auditory function.
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Specifications

Form

Lyophilized

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General info

Function

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

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Product protocols

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Target data

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
See full target information SERPINB6
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