Recombinant Human SerpinB8 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The function of SerpinB8 involves the inhibition of excessive proteolytic activity which is vital for maintaining cell homeostasis and tissue integrity. While SerpinB8 does not form part of a defined protein complex its activity helps control protease actions that could otherwise lead to cell damage or apoptosis. In skin tissue SerpinB8 manages protease levels during inflammation and wound healing processes hinting at its protective role under stress conditions.

Pathways

SerpinB8 contributes to the regulation of the inflammation and wound healing pathways. It interacts with proteases such as cathepsin G and elastase which are important for these biological functions. By inhibiting these proteases SerpinB8 preserves tissue integrity and prevents exaggerated immune responses linking it closely to other serpins that perform similar regulatory roles.