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AB182804

Recombinant Human SERPINI2 protein

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Recombinant Human SERPINI2 protein is a Human Full Length protein, in the 21 to 405 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

MEPI, PI14, SERPINI2, Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His-T7 tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75830

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHENLYFQGGEFCSAMKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL","proteinLength":"Full Length","predictedMolecularWeight":"47.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":405,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75830","tags":[{"tag":"His-T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERPINI2 also known as Neuroserpin is a serine protease inhibitor with a molecular weight of approximately 44 kDa. This protein plays an important role in inhibiting proteolytic enzymes in the nervous system and other tissues. It is primarily expressed in the pancreas but it is also found in the central nervous system particularly in organs like the brain and spinal cord. The protein showcases moderate expression in tissues including lungs and kidneys reflecting its widespread regulatory functions across diverse physiological environments.
Biological function summary

SERPINI2 interacts closely with serine proteases like tissue plasminogen activator to maintain cellular homeostasis by preventing excessive proteolysis. This regulatory action is important in processes such as fibrotic response maintaining extracellular matrix integrity and facilitating normal cellular turnover. SERPINI2 operates by forming complexes with its target proteins inhibiting their proteolytic activity and therefore modulating various cellular activities especially where proteolysis needs to be checked to prevent tissue damage.

Pathways

SERPINI2 finds itself involved in regulatory pathways including the fibrinolytic system and the inflammatory response system. Its modulation of plasminogen activator activity links SERPINI2 to the plasminogen activation pathway essential for processes like tissue remodeling and repair. Additionally it shares functional interactions with proteins like plasminogen activator inhibitor 1 (PAI-1) working in tandem to optimize fibrinolytic balance and influence the turnover of the extracellular matrix.

SERPINI2 has been implicated in conditions such as pancreatic cancer and respiratory diseases like chronic obstructive pulmonary disease (COPD). In pancreatic cancer altered regulation of SERPINI2 has been associated with tumor progression due to changes in proteolytic control within the tumor microenvironment. Furthermore in respiratory disorders it connects to proteins like alpha-1-antitrypsin where dysregulated protease inhibition can exacerbate tissue destruction and inflammation common features of COPD.
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Specifications

Form

Liquid

Additional notes

ab182804 is expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.

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General info

Sequence similarities

Belongs to the serpin family.

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Product protocols

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Target data

See full target information SERPINI2
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