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AB153599

Recombinant Human SESN3 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human SESN3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 321 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SEST3, SESN3, Sestrin-3

1 Images
SDS-PAGE - Recombinant Human SESN3 protein (GST tag N-Terminus) (AB153599)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SESN3 protein (GST tag N-Terminus) (AB153599)

ab153599 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P58005

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

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SDS-PAGE - Recombinant Human CHRNB4 protein (GST tag N-Terminus) (AB158120)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSGAFLHFFAF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":321,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P58005","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SESN3 also known as Sestrin 3 is a protein involved in cellular stress response with a mass of approximately 57 kDa. This protein works as an antioxidant and helps in regulating the cellular redox state. SESN3 is expressed in various tissues most prominently in metabolically active tissues such as the liver and muscle. It responds to oxidative stress by influencing antioxidant defense mechanisms and also maintains cellular homeostasis.
Biological function summary

SESN3 plays an important role in metabolic regulation and cellular protection. It activates AMP-activated protein kinase (AMPK) contributing to the suppression of the mammalian target of rapamycin complex 1 (mTORC1) signaling. SESN3 does not exist as a part of a larger protein complex itself but interacts with other proteins to exert its functions. Through these interactions SESN3 helps manage cellular metabolism preventing damage from oxidative stress.

Pathways

SESN3 participates in the PI3K/AKT/mTOR and AMPK signaling pathways both essential for regulating cell growth and energy metabolism. It interacts with proteins such as mTOR and TSC2 (tuberous sclerosis complex 2) which are necessary for balancing cellular growth and nutrient availability. SESN3 modulates these pathways by inhibiting mTORC1 activity impacting processes like protein synthesis and autophagy.

SESN3 has associations with metabolic disorders and cancer. Dysregulation of SESN3 affects pathways like AMPK and mTOR linked to type 2 diabetes and obesity. Additionally changes in SESN3 levels influence tumor growth as SESN3 affects processes involved in cell survival and proliferation. SESN3's interaction with AMPK and mTOR links it to cancerous processes highlighting its potential as a therapeutic target.
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Specifications

Form

Liquid

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General info

Function

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed : 25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).

Sequence similarities

Belongs to the sestrin family.

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Product protocols

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Target data

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed : 25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
See full target information SESN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neuroscience letters 684:35-41 PubMed29966750

2018

Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuo Miki,Kunikazu Tanji,Fumiaki Mori,Jun Utsumi,Hidenao Sasaki,Akiyoshi Kakita,Hitoshi Takahashi,Koichi Wakabayashi
View all publications
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Product promise

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