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Recombinant human SET7 protein is a Human Full Length protein, in the 1 to 366 aa range, expressed in Baculovirus infected Sf9, with >95% purity and suitable for SDS-PAGE, WB, FuncS.
Alternative names=Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, H3-K4-HMTase SETD7, KMT7, KIAA1717, SETD7, SET7, SET9
>95% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
SDS-PAGE, WB, FuncS
Yes
M D S D D E M V E E A V E G H L D D D G L P H G F C T V T Y S S T D R F E G N F V H G E K N G R G K F F F F D G S T L E G Y Y V D D A L Q G Q G V Y T Y E D G G V L Q G T Y V D G E L N G P A Q E Y D T D G R L I F K G Q Y K D N I R H G V C W I Y Y P D G G S L V G E V N E D G E M T G E K I A Y V Y P D E R T A L Y G K F I D G E M I E G K L A T L M S T E E G R P H F E L M P G N S V Y H F D K S T S S C I S T N A L L P D P Y E S E R V Y V A E S L I S S A G E G L F S K V A V G P N T V M S F Y N G V R I T H Q E V D S R D W A L N G N T L S L D E E T V I D V P E P Y N H V S K Y C A S L G H K A N H S F T P N C I Y D M F V H P R F G P I K C I R T L R A V E A D E E L T V A Y G Y D H S P P G K S G P E A P E W Y Q V E L K A F Q A T Q Q K
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Recombinant human SET7 protein is a Human Full Length protein, in the 1 to 366 aa range, expressed in Baculovirus infected Sf9, with >95% purity and suitable for SDS-PAGE, WB, FuncS.
Alternative names=Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, H3-K4-HMTase SETD7, KMT7, KIAA1717, SETD7, SET7, SET9
>95% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
SDS-PAGE, WB, FuncS
Yes
The specific activity of ab167960 was determined to be 40 nmol/min/mg as per activity assay protocol.
75 kDa
1 to 366
M D S D D E M V E E A V E G H L D D D G L P H G F C T V T Y S S T D R F E G N F V H G E K N G R G K F F F F D G S T L E G Y Y V D D A L Q G Q G V Y T Y E D G G V L Q G T Y V D G E L N G P A Q E Y D T D G R L I F K G Q Y K D N I R H G V C W I Y Y P D G G S L V G E V N E D G E M T G E K I A Y V Y P D E R T A L Y G K F I D G E M I E G K L A T L M S T E E G R P H F E L M P G N S V Y H F D K S T S S C I S T N A L L P D P Y E S E R V Y V A E S L I S S A G E G L F S K V A V G P N T V M S F Y N G V R I T H Q E V D S R D W A L N G N T L S L D E E T V I D V P E P Y N H V S K Y C A S L G H K A N H S F T P N C I Y D M F V H P R F G P I K C I R T L R A V E A D E E L T V A Y G Y D H S P P G K S G P E A P E W Y Q V E L K A F Q A T Q Q K
Full Length
No
Recombinant
Human
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Liquid
Assessed by densitometry. Affinity purified.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Nucleus
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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