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AB86915

Recombinant Human SF20 protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human SF20 protein (His tag N-Terminus) is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

C19orf10, MYDGF, Myeloid-derived growth factor

1 Images
SDS-PAGE - Recombinant Human SF20 protein (His tag N-Terminus) (AB86915)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SF20 protein (His tag N-Terminus) (AB86915)

15% SDS-PAGE analysis of 3 ug ab86915

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q969H8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q969H8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SF20 also known as IL-25 or IL-TIF is a protein involved in cell signaling mechanisms. It has a molecular mass of around 25 kDa. SF20 shows expression in specific tissues such as the small intestine lung and skin suggesting its role in tissue-specific functions. Its expression pattern might suggest potential roles in mucosal immunity and epithelial functions.
Biological function summary

SF20 acts as a member of the IL-17 cytokine family which mediates inflammatory responses. It often forms part of signaling complexes that involve other cytokines to coordinate immune responses. SF20 exerts its influence by binding to a unique receptor complex activating downstream signaling cascades. This interaction is important in mobilizing immune cells to sites of infection or injury highlighting its role in immune system regulation.

Pathways

SF20 is involved in the Th17 cell differentiation and inflammatory response pathways. It plays a role in modulating the activities of STAT3 and NF-kB pathways which are essential in inflammation and immune regulation. SF20 interacts with other proteins such as IL-17A and IL-17F which aid in the amplification of immune signals and inflammation.

SF20 has implications in conditions like asthma and inflammatory bowel disease (IBD). Its involvement in chronic inflammation links it to these diseases. SF20 can interact with proteins like IL-23 in the context of Th17-mediated inflammatory responses. Targeting SF20 and its signaling pathways presents potential therapeutic opportunities for modulating immune responses in such diseases.
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Specifications

Form

Liquid

Additional notes

ab86915 was purified using conventional chromatography techniques, after refolding of the isolated inclusion bodies in a renaturation buffer.

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General info

Function

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed : 25581518).

Sequence similarities

Belongs to the MYDGF family.

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Product protocols

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Target data

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed : 25581518).
See full target information MYDGF
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 11:209-221 PubMed33391471

2021

Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Wang,Jie Mao,Tao Zhou,Xingyi Chen,Haoyang Tu,Jinyan Ma,Yixuan Li,Yushi Ding,Yong Yang,Hongxi Wu,Xinying Tang
View all publications
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