Recombinant Human SFRP4 protein (Active)
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- What is this?
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Recombinant Human SFRP4 protein (Active) is a Human Full Length protein, in the 19 to 346 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level.
View Alternative Names
FRPHE, SFRP4, Secreted frizzled-related protein 4, sFRP-4, FrpHE
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human SFRP4 protein (Active) (AB288790)
Mass determination by ESI-TOF.
Predicted MW is 37888.18 Da. (+/- 10 Da by ESI-TOF). Observed MW is 37893.90 Da.
- Biological Activity
Supplier Data
Biological Activity - Recombinant Human SFRP4 protein (Active) (AB288790)
Fully biologically active determined by the dose dependent inhibition of WNT-3a induced Wnt/ß-catenin activation in HEK293 TCF/LEF luciferase reporter cell line. ED50 is ≤ 52.4 ng/ml, corresponding to a specific activity of 1.9 x 10^4 units/mg.
- HPLC
Supplier Data
HPLC - Recombinant Human SFRP4 protein (Active) (AB288790)
HPLC analysis of ab288790
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human SFRP4 protein (Active) (AB288790)
SDS-PAGE analysis of ab288790
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SFRP4 regulates cell growth and differentiation. It interacts with Wnt ligands preventing them from binding to their receptors. SFRP4 does not typically function as part of a protein complex acting instead as an antagonist on its own. By inhibiting Wnt activity SFRP4 influences embryonic development tissue homeostasis and even cancer progression. The impact of SFRP4 varies depending on the tissue-specific context reflecting its complex biological roles.
Pathways
SFRP4 is significant in the Wnt signaling pathway and the β-catenin independent pathway. By interacting with Wnt ligands SFRP4 can prevent the activation of canonical Wnt/β-catenin signaling a pathway involved in cell fate determination and stem cell renewal. It also influences the non-canonical pathways where the Wnt signaling does not involve β-catenin impacting processes like cell movement and polarity. In these pathways SFRP4 interacts with proteins such as Disheveled and Axin modulating their activities.
Specifications
Form
Lyophilized
General info
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed : 12952927).
Sequence similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Target data
Complementary Products
Product promise
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