Recombinant Human SFTA3 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFTA3 also known as surfactant-associated protein C-term has a mass not well-documented but is part of a family associated with pulmonary surfactant proteins. Researchers detect its expression mostly in lung tissues where it performs specific roles within the pulmonary system. Its presence mainly in the lungs suggests that it plays an essential role in respiratory functions and surfactant homeostasis.

Biological function summary

The expression patterns indicate that SFTA3 contributes significantly to the stability and function of pulmonary surfactants essential for reducing surface tension in the alveoli. Though not a part of any large macromolecular complexes traditionally identified SFTA3 likely interacts with other surfactant proteins like SP-B and SP-C to maintain alveolar stability. These interactions underpin its structural contributions to lung function under regular and stress-related conditions.

Pathways

Studies suggest SFTA3 involves surfactant metabolism pathways contributing to the development and replenishment of lung surfactants. This protein possibly associates with mature surfactant proteins aiding their functional deployment in the respiratory processes. SFTA3's interactions within this pathway relate to proteins such as ATP-binding cassette transporter A3 (ABCA3) known for transferring surfactant precursors and facilitating surfactant homeostasis.

Researchers link SFTA3 roles in surfactant metabolism with respiratory distress syndromes such as neonatal respiratory distress syndrome. Variations or deficiencies in SFTA3 expression may affect surfactant composition which could increase susceptibility to these conditions. The interaction of SFTA3 with proteins like ABCA3 further emphasizes its connection to lung tissue pathophysiology and potentially highlights targets for therapeutic interventions in surfactant-related disorders.