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AB160261

Recombinant Human SGCE/ESG protein

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Recombinant Human SGCE/ESG protein is a Human Full Length protein, in the 1 to 437 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

ESG, UNQ433/PRO840, SGCE, Epsilon-sarcoglycan, Epsilon-SG

1 Images
SDS-PAGE - Recombinant Human SGCE/ESG protein (AB160261)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human SGCE/ESG protein (AB160261)

ab160261 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O43556

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as SGCE.
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Sequence info

[{"sequence":"MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":437,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43556","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SGCE/ESG also known as epsilon-sarcoglycan is a protein that is important in forming components of the sarcoglycan complex. The SGCE/ESG protein has a mass of approximately 48 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Its localization in these muscles suggests an integral role in their structural stability and function.
Biological function summary

The SGCE/ESG protein contributes significantly to the integrity of the dystrophin-glycoprotein complex (DGC). This complex is essential for maintaining the linkage between the cytoskeleton and the extracellular matrix providing mechanical stability to muscle cells during contraction and relaxation. SGCE/ESG is an essential component contributing to the structural organization and proper functioning of muscle fibers.

Pathways

SGCE/ESG is notably involved in the adhesion and signaling pathways within muscle cells. It plays a significant role in the dystroglycan and sarcoglycan complexes. These complexes interact with other proteins like dystrophin and beta-dystroglycan linking the extracellular matrix to the cytoskeleton and mediating signal transduction required for muscle function and repair.

SGCE/ESG mutations are associated with myoclonus-dystonia syndrome a neurological condition that affects movement and posture. The protein's dysfunction disrupts normal communication between muscle cells leading to symptoms characteristic of this disorder. Additionally SGCE/ESG has connections to limb-girdle muscular dystrophy where it interacts with sarcoglycan proteins that when mutated lead to muscle weakness and degeneration.
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Specifications

Form

Liquid

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General info

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Sequence similarities

Belongs to the sarcoglycan alpha/epsilon family.

Post-translational modifications

N-glycosylated.. Ubiquitinated, leading to its degradation by the proteasome.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
See full target information SGCE
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