Recombinant human SGK2 protein (Active)
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Recombinant human SGK2 protein (Active) is a Human Full Length protein, in the 1 to 427 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
View Alternative Names
Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2
- Biological Activity
Supplier Data
Biological Activity - Recombinant human SGK2 protein (Active) (AB261921)
The specific activity of ab261921 was determines to be 74 nmol/min/mg as per activity assay protocol.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human SGK2 protein (Active) (AB261921)
SDS-PAGE analysis of ab261921.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SGK2 contributes to cellular signaling processes that regulate sodium and potassium ion channels impacting cellular homeostasis. SGK2 does not function as part of a larger complex but still exerts significant influence on cell volume regulation and osmoregulation. It modulates activities of ion transporters and other kinases influencing fluid absorption in epithelial cells and metabolic processes highlighting its relevance in both normal physiology and pathophysiology.
Pathways
SGK2 integrates into signaling networks including the PI3K/AKT pathway and the mTOR pathway. Within these pathways SGK2 serves as a downstream target of PI3K activity participating in cellular responses to insulin and growth factors. The kinase interacts closely with proteins like AKT maintaining cell survival and metabolic balance. SGK2's role in these pathways points to its influence on anabolic processes and adaptive cell responses.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels : SCNN1A/ENAC, K(+) channels : KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter : SLC6A19, glutamate transporter : SLC1A6/EAAT4, glutamate receptors : GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger : SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-translational modifications
Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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