Recombinant human SGK3 protein
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Recombinant human SGK3 protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >85%, suitable for SDS-PAGE, FuncS.
View Alternative Names
CISK, SGKL, SGK3, Serine/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like
- FuncS
Supplier Data
Functional Studies - Recombinant human SGK3 protein (AB55673)
The specific activity of SGK3 (ab55673) was determined to be 90 nmol/min/mg as per activity assay protocol.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human SGK3 protein (AB55673)
SDS PAGE analysis of ab55673
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human SGK3 protein (AB55673)
SDS Page analysis of ab55673
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SGK3 contributes to cellular growth and metabolism. This protein integrates signals involved in the response to oxidative stress and plays a part in the cellular response to environmental changes. As a member of the AGC kinase family SGK3 shares structural and functional similarities with AKT another significant kinase involved in growth regulation and apoptosis control.
Pathways
SGK3 functions within the PI3K/AKT signaling pathway and also interacts in the mTOR signaling network. These pathways are critical for regulating cell proliferation survival and metabolism. SGK3 can phosphorylate several downstream targets including FOXO3a and NDRG1 contributing to cellular resistance to stress and promoting survival pathways.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels : SCNN1A/ENAC and SCN5A, K(+) channels : KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels : TRPV5 and TRPV6, chloride channel : BSND, creatine transporter : SLC6A8, Na(+)/dicarboxylate cotransporter : SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter : SLC34A2/NAPI-2B, amino acid transporters : SLC1A5/ASCT2 and SLC6A19, glutamate transporters : SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors : GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger : SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-translational modifications
Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
Subcellular localisation
Early endosome
Target data
Product promise
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