Recombinant Human SH3BGRL protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3BGRL also known as SH3 domain-binding glutamic acid-rich protein-like is a scaffold protein involved in signaling pathways. It has a molecular weight of approximately 13 kDa and is widely expressed in various tissues including the brain liver and immune cells. The protein contains a phosphotyrosine-binding domain enabling interactions with phosphorylated proteins. This ability allows SH3BGRL to modulate signaling processes essential for cellular communication and function.

Biological function summary

SH3 domain-containing proteins like SH3BGRL facilitate multiple cellular processes by interacting with proteins involved in signal transduction pathways. It potentially forms part of larger protein complexes serving as an adaptor or mediator in these complexes. SH3BGRL can influence cell proliferation differentiation and immune responses by affecting downstream signaling events. Its rich domain structure suggests a role in maintaining the balance of specific signaling cascades helping cells respond properly to external stimuli.

Pathways

SH3BGRL participates in the regulation of the mitogen-activated protein kinase (MAPK) and JAK-STAT pathways. These pathways are important for cell signaling related to growth division and apoptosis. Within the MAPK pathway SH3BGRL can interact with kinases like ERK showing its influence on cellular functions. In the JAK-STAT pathway SH3BGRL may assist in the modulation of cytokine signaling by impacting interactions with receptor-associated phosphates. SH3BGRL's interactions with these proteins emphasize its significance in maintaining normal cellular dynamics.

Research links SH3BGRL to cancer and autoimmune diseases. Dysregulation of MAPK and JAK-STAT pathways where SH3BGRL has a role frequently occurs in various cancers contributing to uncontrolled cell growth and survival. In autoimmune diseases abnormal SH3BGRL expression might relate to faulty immune signal regulation along with proteins such as STAT3. These connections suggest that SH3BGRL may serve as a potential biomarker or therapeutic target in disease contexts.