Recombinant Human SH3BGRL2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3BGRL2 also known as SH3 domain-binding glutamic acid-rich-like protein 2 is an intracellular protein that interacts with SH3 domains commonly found in signaling proteins. This protein has a molecular mass of approximately 28 kDa. SH3BGRL2 is broadly expressed in several human tissues with notable expression in liver heart and kidney. Its mechanical role involves interactions that modulate cellular signaling pathways potentially influencing cell communication and function.

Biological function summary

The role of SH3BGRL2 includes participating in signaling cascades. It does not exist as part of a major known complex but likely influences these cascades by modulating the activity of proteins with SH3 domains. This interaction facilitates various cellular processes demonstrating its importance in cellular functionality and response.

Pathways

The involvement of SH3BGRL2 extends to important signaling processes like the MAPK/ERK pathway. By modulating proteins such as growth factor receptor-bound protein 2 (Grb2) SH3BGRL2 impacts cell proliferation and differentiation. Another related pathway is the JNK signaling pathway where similar interactions may influence apoptotic processes linking SH3BGRL2 to cellular survival and stress responses.

SH3BGRL2 has associations with certain cancer types and neurodegenerative diseases. Changes in its expression levels or functional dysregulation can contribute to the progression of hepatocellular carcinoma potentially interacting with proteins like the oncogene RAS. Additionally SH3BGRL2 may relate to Alzheimer's disease given its potential influence on neuronal signaling pathways critical for cell survival and communication possibly through connections with APP the amyloid precursor protein.