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AB202261

Recombinant Human SH3GL3 protein (His tag)

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Recombinant Human SH3GL3 protein (His tag) is a Human Full Length protein, in the 1 to 347 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CNSA3, SH3D2C, SH3GL3, Endophilin-A3, EEN-B2, Endophilin-3, SH3 domain protein 2C, SH3 domain-containing GRB2-like protein 3

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SDS-PAGE - Recombinant Human SH3GL3 protein (His tag) (AB202261)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SH3GL3 protein (His tag) (AB202261)

15% SDS-PAGE analysis of ab202261 (3 μg)

SDS-PAGE - Recombinant Human SH3GL3 protein (His tag) (AB202261)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SH3GL3 protein (His tag) (AB202261)

SDS PAGE analysis using 3µg ab202261 stained with coomassie blue

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q99963

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ","proteinLength":"Full Length","predictedMolecularWeight":"41.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":347,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99963","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3GL3 also known as endophilin A3 is a protein with a molecular mass of approximately 40 kDa. It functions mechanically through its SH3 domain which facilitates interaction with proline-rich motifs in other proteins part of various cellular processes. Expressed mainly in the brain and neural tissues SH3GL3 plays significant roles in intracellular signaling and membrane dynamics. Its presence in neuronal tissue suggests an involvement in key neurological processes.
Biological function summary

SH3GL3 interacts with other proteins as part of the endophilin protein family involved in endocytosis and synaptic vesicle recycling. It acts as an adaptor linking intracellular signaling proteins to membrane-bound receptors influencing the way neurons communicate and adapt to changes. SH3GL3 helps regulate the formation and maintenance of synaptic connections ensuring proper neural network function.

Pathways

SH3GL3 participates in the regulation of the endocytosis pathway engaging in vital neuron communication mechanisms. It connects with proteins like dynamin and synaptojanin to modulate vesicle scission and recycling. Through the Ras signaling pathway it further affects synaptic plasticity and cellular responses to external stimuli supporting the adaptability of neural tissues.

SH3GL3 associates with neurological conditions including Alzheimer's disease and schizophrenia. In Alzheimer's altered interactions with proteins like amyloid precursor protein (APP) might disrupt synaptic function contributing to cognitive decline. In schizophrenia modifications in endocytic and signaling pathways involving SH3GL3 and proteins like neuregulin-1 could affect neurotransmission leading to symptoms commonly observed in the disorder.
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Specifications

Form

Liquid

Additional notes

ab202261 was purified using conventional chromatography.

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General info

Function

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Sequence similarities

Belongs to the endophilin family.

Subcellular localisation

Early endosome membrane

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Product protocols

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Target data

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
See full target information SH3GL3
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Complementary Products

Primary Antibodies

AB184008

Anti-SH3GL3 antibody

Western blot - Anti-SH3GL3 antibody (AB184008)

  • 0
  • 0
Assay Kits

AB284024

Human SH3GL3 ELISA Kit

Recombinant

Functional Studies - Human SH3GL3 ELISA Kit (AB284024)

  • 0
  • 0

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