Recombinant Human SHCBP1 protein is a Human Full Length protein, in the 1 to 672 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A D G S L T G G G L E A A A M A P E R T G W A V E Q E L A S L E K G L F Q D E D S C S D C S Y R D K P G S S L Q S F M P E G K T F F P E I F Q T N Q L L F Y E R F R A Y Q D Y I L A D C K A S E V Q E F T A E F L E K V L E P S G W R A V W H T N V F K V L V E I T D V D F A A L K A V V R L A E P Y L C D S Q V S T F T M E C M K E L L D L K E H R L P L Q E L W V V F D D S G V F D Q T A L A I E H V R F F Y Q N I W R S W D E E E E D E Y D Y F V R C V E P R L R L H Y D I L E D R V P S G L I V D Y H N L L S Q C E E S Y R K F L N L R S S L S N C N S D S E Q E N I S M V E G L K L Y S E M E Q L K Q K L K L I E N P L L R Y V F G Y Q K N S N I Q A K G V R S S G Q K I T H V V S S T M M A G L L R S L L T D R L C Q E P G E E E R E I Q F H S D P L S A I N A C F E G D T V I V C P G H Y V V H G T F S I A D S I E L E G Y G L P D D I V I E K R G K G D T F V D C T G A D I K I S G I K F V Q H D A V E G I L I V H R G K T T L E N C V L Q C E T T G V T V R T S A E F L M K N S D L Y G A K G A G I E I Y P G S Q C T L S D N G I H H C K E G I L I K D F L D E H Y D I P K I S M V N N I I H N N E G Y G V V L V K P T I F S D L Q E S A E D G T E E N K A L K I Q T S G E P D V A E R V D L E E L I E C A T G K M E L C A R T D P S E Q V E G N C E I V N E L I A A S T Q K G Q I K K K R L S E L G I T Q A D D N L M S Q E M F V G I V G N Q F K W N G K G S F G T F L F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
Alternative names
SHC SH2 domain-binding protein 1, SHCBP1
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Recombinant Human SHCBP1 protein is a Human Full Length protein, in the 1 to 672 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8NEM2-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A D G S L T G G G L E A A A M A P E R T G W A V E Q E L A S L E K G L F Q D E D S C S D C S Y R D K P G S S L Q S F M P E G K T F F P E I F Q T N Q L L F Y E R F R A Y Q D Y I L A D C K A S E V Q E F T A E F L E K V L E P S G W R A V W H T N V F K V L V E I T D V D F A A L K A V V R L A E P Y L C D S Q V S T F T M E C M K E L L D L K E H R L P L Q E L W V V F D D S G V F D Q T A L A I E H V R F F Y Q N I W R S W D E E E E D E Y D Y F V R C V E P R L R L H Y D I L E D R V P S G L I V D Y H N L L S Q C E E S Y R K F L N L R S S L S N C N S D S E Q E N I S M V E G L K L Y S E M E Q L K Q K L K L I E N P L L R Y V F G Y Q K N S N I Q A K G V R S S G Q K I T H V V S S T M M A G L L R S L L T D R L C Q E P G E E E R E I Q F H S D P L S A I N A C F E G D T V I V C P G H Y V V H G T F S I A D S I E L E G Y G L P D D I V I E K R G K G D T F V D C T G A D I K I S G I K F V Q H D A V E G I L I V H R G K T T L E N C V L Q C E T T G V T V R T S A E F L M K N S D L Y G A K G A G I E I Y P G S Q C T L S D N G I H H C K E G I L I K D F L D E H Y D I P K I S M V N N I I H N N E G Y G V V L V K P T I F S D L Q E S A E D G T E E N K A L K I Q T S G E P D V A E R V D L E E L I E C A T G K M E L C A R T D P S E Q V E G N C E I V N E L I A A S T Q K G Q I K K K R L S E L G I T Q A D D N L M S Q E M F V G I V G N Q F K W N G K G S F G T F L F
- Accession
- Q8NEM2
- Protein length
- Full Length
- Amino acids
- 1 to 672
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
- Subcellular localisation
- Cytoskeleton, Spindle
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SHCBP1 also known as SHC SH2-Domain Binding Protein 1 is a 72 kDa protein involved in cell cycle regulation. This protein exhibits a significant role in the interaction with the SHC1 adaptor protein influencing the signaling pathways activated by receptor tyrosine kinases. SHCBP1 shows high expression in tissues with active cell division such as the testis and several cancer cell lines. Its localization within cells includes both the cytoplasm and nucleus indicating diverse functional roles.
- Biological function summary
SHCBP1 aids in processes fundamental to cell proliferation and differentiation. It does not operate alone but participates in larger protein complexes that modulate cell division events. By interacting with other signaling molecules SHCBP1 becomes an important player in mitotic spindle assembly and cytokinesis. Its presence in complexes highlights its interaction with additional proteins which regulates the progression of the cell cycle.
- Pathways
SHCBP1 resides in pathways linked to the regulation of mitosis and cell proliferation. This protein plays an important role in the PI3K/Akt signaling pathway which is pivotal for cell growth and survival. Additionally ties to proteins like PLK1 and Aurora B further emphasize SHCBP1's integration into cell cycle regulation networks. These interactions ensure proper cellular responses to growth signals and accurate chromosome segregation during mitosis.
- Associated diseases and disorders
SHCBP1 connections to cancer and infertility are notable. In several types of cancer overexpression of SHCBP1 associates with tumor progression and poor prognosis often through its interaction with oncogenic proteins like Cyclin D1. In cases of male infertility dysregulation of SHCBP1 impacts spermatogenesis due to its essential role in cell cycle and division. Understanding these associations offers potential pathways for therapeutic interventions targeting SHCBP1-related mechanisms.
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1 product image
SDS-PAGE - Recombinant Human SHCBP1 protein (ab164118)
ab164118 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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