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AB164118

Recombinant Human SHCBP1 protein (GST tag N-Terminus)

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Recombinant Human SHCBP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 672 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SHC SH2 domain-binding protein 1, SHCBP1

1 Images
SDS-PAGE - Recombinant Human SHCBP1 protein (AB164118)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SHCBP1 protein (AB164118)

ab164118 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8NEM2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMPEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNEGYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCARTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFKWNGKGSFGTFLF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":672,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NEM2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHCBP1 also known as SHC SH2-Domain Binding Protein 1 is a 72 kDa protein involved in cell cycle regulation. This protein exhibits a significant role in the interaction with the SHC1 adaptor protein influencing the signaling pathways activated by receptor tyrosine kinases. SHCBP1 shows high expression in tissues with active cell division such as the testis and several cancer cell lines. Its localization within cells includes both the cytoplasm and nucleus indicating diverse functional roles.
Biological function summary

SHCBP1 aids in processes fundamental to cell proliferation and differentiation. It does not operate alone but participates in larger protein complexes that modulate cell division events. By interacting with other signaling molecules SHCBP1 becomes an important player in mitotic spindle assembly and cytokinesis. Its presence in complexes highlights its interaction with additional proteins which regulates the progression of the cell cycle.

Pathways

SHCBP1 resides in pathways linked to the regulation of mitosis and cell proliferation. This protein plays an important role in the PI3K/Akt signaling pathway which is pivotal for cell growth and survival. Additionally ties to proteins like PLK1 and Aurora B further emphasize SHCBP1's integration into cell cycle regulation networks. These interactions ensure proper cellular responses to growth signals and accurate chromosome segregation during mitosis.

SHCBP1 connections to cancer and infertility are notable. In several types of cancer overexpression of SHCBP1 associates with tumor progression and poor prognosis often through its interaction with oncogenic proteins like Cyclin D1. In cases of male infertility dysregulation of SHCBP1 impacts spermatogenesis due to its essential role in cell cycle and division. Understanding these associations offers potential pathways for therapeutic interventions targeting SHCBP1-related mechanisms.
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Specifications

Form

Liquid

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General info

Function

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
See full target information SHC SH2 domain-binding protein 1
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