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AB161754

Recombinant Human SHK protein (GST tag N-Terminus)

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Recombinant Human SHK protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 478 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CARKL, SHPK, Sedoheptulokinase, SHK, Carbohydrate kinase-like protein

1 Images
SDS-PAGE - Recombinant Human SHK protein (GST tag N-Terminus) (AB161754)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SHK protein (GST tag N-Terminus) (AB161754)

ab161754 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9UHJ6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Recombinant Human WSB2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human WSB2 protein (GST tag N-Terminus) (AB163264)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as CARKL.
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Sequence info

[{"sequence":"MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQEWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":478,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UHJ6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHK also known as Shaker-related voltage-gated potassium channel or Kv1.3 functions in the regulation of ion flow across the cell membrane. It belongs to the voltage-gated potassium channel family and has a molecular mass of approximately 57 kDa. Expression of SHK occurs mainly in the nervous system including the brain and in lymphocytes playing an important role in maintaining the cellular membrane potential and modulating action potentials.
Biological function summary

This channel is involved in repolarizing the neuronal membrane following action potentials. SHK channels contribute significantly to the excitability of neurons and T cells facilitating their activation and response. The protein does not exist in isolation but forms part of a complex with other ion channels impacting cellular excitability and immune responses. This interaction with other ion channels allows it to fine-tune the physiological responses important for cellular signaling.

Pathways

SHK participates in important neurological and immune system pathways. It is part of the neuronal signaling pathways where it affects neurotransmitter release. Additionally SHK aligns with the JAK-STAT pathway in T cells influencing their maturation and function. SHK operates alongside proteins like Kv1.1 in these pathways interacting to modulate channel conductance and overall cellular activity.

It is associated with multiple sclerosis and type 1 diabetes. SHK channel dysregulation affects the immune system contributing to aberrant immune responses seen in these autoimmune diseases. The protein interacts with other channels including Kv1.5 influencing disease progression. Targeting SHK for therapeutic intervention offers possible strategies for managing these conditions by correcting the dysregulated channel activity.
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Specifications

Form

Liquid

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General info

Function

Acts as a modulator of macrophage activation through control of glucose metabolism.

Sequence similarities

Belongs to the FGGY kinase family.

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Product protocols

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Target data

Acts as a modulator of macrophage activation through control of glucose metabolism.
See full target information SHPK
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