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Recombinant Human SIGLEC15 protein (Tagged) (Biotin) is a Human Fragment protein, in the 20 to 263 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human SIGLEC15 protein (Tagged) (Biotin) (AB271740), expandable thumbnail

Key facts

Purity

>=90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus
Fc tag C-Terminus

Applications

SDS-PAGE

Biologically active

No

Conjugation

Biotin

Amino acid sequence

F V R T K I D T T E N L L N T E V H S S P A Q R W S M Q V P P E V S A E A G D A A V L P C T F T H P H R H Y D G P L T A I W R A G E P Y A G P Q V F R C A A A R G S E L C Q T A L S L H G R F R L L G N P R R N D L S L R V E R L A L A D D R R Y F C R V E F A G D V H D R Y E S R H G V R L H V T A A P R I V N I S V L P S P A H A F R A L C T A E G E P P P A L A W S G P A L G N S L A A V R S P R E G H G H L V T A E L P A L T H D G R Y T C T A A N S L G R S E A S V Y L F R F H G A S G A S T

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Binds sialylated glycoproteins.

Alternative names

Recommended products

Recombinant Human SIGLEC15 protein (Tagged) (Biotin) is a Human Fragment protein, in the 20 to 263 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE.

Key facts

Purity

>=90% SDS-PAGE

Expression system

HEK 293 cells

Applications

SDS-PAGE

Conjugation

Biotin

Accession
Q6ZMC9-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

Sequence info

Amino acid sequence

F V R T K I D T T E N L L N T E V H S S P A Q R W S M Q V P P E V S A E A G D A A V L P C T F T H P H R H Y D G P L T A I W R A G E P Y A G P Q V F R C A A A R G S E L C Q T A L S L H G R F R L L G N P R R N D L S L R V E R L A L A D D R R Y F C R V E F A G D V H D R Y E S R H G V R L H V T A A P R I V N I S V L P S P A H A F R A L C T A E G E P P P A L A W S G P A L G N S L A A V R S P R E G H G H L V T A E L P A L T H D G R Y T C T A A N S L G R S E A S V Y L F R F H G A S G A S T

Accession

Q6ZMC9

Protein length

Fragment

Predicted molecular weight

55 kDa

Amino acids

20 to 263

Nature

Recombinant

Tags

Avi tag C-Terminus, Fc tag C-Terminus

Specifications

Form

Liquid

General info

Function

Binds sialylated glycoproteins.

Sequence similarities

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Storage information

Avoid freeze / thaw cycle, Store in the dark

Notes

Enzymatically biotin-labeled using Avi-tag™ technology

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SIGLEC15 also known as sialic acid-binding Ig-like lectin 15 is a transmembrane protein with an approximate mass of 50 kDa. This protein is a member of the SIGLEC family that binds sialic acids on glycoproteins and glycolipids. SIGLEC15 is highly expressed in cells of the osteoclast lineage and some other immune cells. It typically functions as a receptor that can modulate immune cell interactions and signaling by recognizing and binding to sialylated glycans on other cells.

Biological function summary

SIGLEC15 plays roles in modulating the immune system and bone remodeling processes. It is not usually part of a larger complex but primarily acts as a cell surface receptor. SIGLEC15 helps regulate osteoclast differentiation and activity which are important for maintaining bone homeostasis. It modulates immune responses by interacting with other immune cells which can dampen or activate immune signaling pathways based on the cellular context.

Pathways

SIGLEC15 influences both immune signaling and bone metabolism pathways. It is involved in the RANKL-mediated osteoclastogenesis pathway which is critical for the formation and activation of osteoclasts. Within these pathways SIGLEC15 can relate to other proteins like RANK and RANKL that are essential in osteoclast development and function. Through its expression and interactions SIGLEC15 plays key roles in the regulation of immune and skeletal systems.

Associated diseases and disorders

SIGLEC15 plays a significant role in osteoporosis and certain cancers. In osteoporosis SIGLEC15 expression in osteoclasts is elevated which can lead to increased bone resorption and weakened bones. In cancer its expression on tumor-associated macrophages and other cells can help tumors evade immune surveillance. In such conditions proteins like RANK RANKL and other immune checkpoint proteins may also be implicated providing potential targets for therapeutic intervention alongside SIGLEC15.

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1 product image

  • SDS-PAGE - Recombinant Human SIGLEC15 protein (Tagged) (Biotin) (ab271740), expandable thumbnail

    SDS-PAGE - Recombinant Human SIGLEC15 protein (Tagged) (Biotin) (ab271740)

    SDS-PAGE analysis of 4 μg ab271740.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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