Recombinant Human SIT protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SIT protein also known as SLP-76 Interacting Protein weighs approximately 50 kDa and plays a mechanical role in the immune system. SIT is a transmembrane adaptor protein mostly found in T-cells. It lacks intrinsic kinase activity but contains several important motifs that facilitate protein-protein interactions. These interactions are important in immune cell signaling. SIT is primarily observed in hematopoietic tissues indicating its significant presence in cells related to immune response.

Biological function summary

SIT plays an important role in regulating T-cell receptor (TCR) signaling. By participating in the assembly of signaling complexes it modulates the strength and duration of TCR signals. SIT does not act alone but often interacts with other adaptor proteins such as LAT (Linker of Activated T cells) and GRB2 (Growth Factor Receptor-Bound Protein 2). This interaction framework contributes to the modulation of downstream cellular responses affecting activation and differentiation within the T-cell population.

Pathways

SIT engages heavily in the TCR signaling pathway. In this pathway SIT works alongside LAT and another protein called ZAP-70 (Zeta-chain-associated protein kinase 70) to propagate key signaling events. SIT's role in signal transduction implies it indirectly influences the MAPK/ERK pathway a critical route for cell proliferation differentiation and apoptosis. Through these pathways SIT ensures that T-cells respond appropriately to antigens maintaining immune system homeostasis.

SIT is linked to conditions like autoimmune diseases and immunodeficiencies. Abnormal SIT function or expression can lead to improper T-cell signaling contributing to diseases such as Systemic Lupus Erythematosus (SLE) and Severe Combined Immunodeficiency (SCID). In these disorders dysregulated interaction with proteins like LAT and ZAP-70 further exacerbates immune system dysfunction highlighting the importance of SIT in maintaining immune health.