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AB163604

Recombinant Human SLAIN2 protein (GST tag N-Terminus)

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Recombinant Human SLAIN2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 298 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1458, SLAIN2, SLAIN motif-containing protein 2

1 Images
SDS-PAGE - Recombinant Human SLAIN2 protein (GST tag N-Terminus) (AB163604)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SLAIN2 protein (GST tag N-Terminus) (AB163604)

ab163604 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9P270

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":298,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9P270","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLAIN2 also known as SLAIN motif-containing protein 2 is a microtubule-associated protein with an approximate mass of 58 kDa. It localizes predominantly in the cytoplasm. SLAIN2 binds to microtubules directly and regulates their dynamics by influencing polymerization and depolymerization processes. It participates actively in controlling microtubule stability and cellular organization. Expression of SLAIN2 is widely observed across different tissues without restriction to a particular cell type.
Biological function summary

The protein modulates microtubule behavior by interacting with other microtubule plus-end tracking proteins such as those involved in spindle positioning and mitotic progression. SLAIN2 becomes part of complexes that contain proteins like Dishevelled EML1 and COL23A1 contributing to cellular functions that require dynamic cytoskeletal rearrangements. Its role extends to managing essential cellular activities such as cell division intracellular transport and cell migration.

Pathways

Microtubule dynamics regulated by SLAIN2 play a role in the Wnt signaling pathway and the cell cycle pathway. In the Wnt signaling pathway SLAIN2 interacts with proteins like APC and GSK3B. It aids in the proper alignment and segregation of chromosomes during mitosis in the cell cycle pathway facilitating appropriate cell cycle progression. These interactions help coordinate cellular proliferation and differentiation processes ensuring cell integrity and function.

SLAIN2 engages in processes linked to cancer and neurodegenerative diseases. Aberrations in its expression or function can lead to defects in cell cycle control or neuro underlying these conditions. It associates with proteins like TP53 in oncogenic pathways and tau protein in neurodegenerative pathways contributing to pathologies when microtubule dynamics become dysregulated. Understanding SLAIN2's function and connections daily could open new therapeutic avenues for related diseases.
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Specifications

Form

Liquid

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General info

Function

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.

Sequence similarities

Belongs to the SLAIN motif-containing family.

Post-translational modifications

Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.
See full target information SLAIN2
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