Recombinant Human SLAP2 protein (denatured)
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Recombinant Human SLAP2 protein (denatured) is a Human Full Length protein, in the 1 to 261 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
View Alternative Names
C20orf156, SLAP2, SLA2, Src-like-adapter 2, Modulator of antigen receptor signaling, Src-like adapter protein 2, MARS, SLAP-2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human SLAP2 protein (denatured) (AB174415)
15% SDS-PAGE analysis of ab174415 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SLAP2 has a major role in regulating the immune response. By forming complexes with the components of the signal transduction machinery SLAP2 modulates the activity of key receptors such as the T-cell receptor (TCR) and B-cell receptor (BCR). These interactions influence cellular responses such as proliferation differentiation and apoptosis. Through its action SLAP2 acts as a negative regulator preventing overactivation of immune responses and maintaining homeostasis.
Pathways
Studies have shown that SLAP2 participates in both the T-cell receptor signaling pathway and the B-cell receptor signaling pathway. In these pathways SLAP2 interacts with kinases associated with these receptors such as Lck and Fyn influencing downstream signaling events. SLAP2 can inhibit excessive activation of these pathways by promoting the degradation of key signaling molecules ensuring that cells respond appropriately to external signals during immune activation.
Specifications
Form
Liquid
General info
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Post-translational modifications
Phosphorylated by CSF1R.
Target data
Complementary Products
Product promise
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