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AB314520

Recombinant human SLC23A2 protein (His tag)

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Recombinant human SLC23A2 protein (His tag) is a Human Full Length protein, in the 1 to 650 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2, SLC23A2, Solute carrier family 23 member 2, Na(+)/L-ascorbic acid transporter 2, Nucleobase transporter-like 1 protein, Sodium-dependent vitamin C transporter 2, Yolk sac permease-like molecule 2, hSVCT2

1 Images
SDS-PAGE - Recombinant human SLC23A2 protein (His tag) (AB314520)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human SLC23A2 protein (His tag) (AB314520)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UGH3

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20degC/-80degC. Our default final concentration of glycerol is 50%.
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Sequence info

[{"sequence":"MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG","proteinLength":"Full Length","predictedMolecularWeight":"71.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":650,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UGH3","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C|-20°C|-80°C
Appropriate long-term storage conditions
-20°C|-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC23A2 also known as SVCT2 is a sodium-dependent vitamin C transporter with a molecular mass of approximately 71 kDa. This protein functions by facilitating the active transport of vitamin C (ascorbic acid) across cellular membranes using the sodium gradient as a driving force. SLC23A2 is expressed in a variety of tissues prominently in the brain eyes and adrenal glands indicating its significant role in transporting vitamin C to vital organs that are sensitive to oxidative stress.
Biological function summary

SLC23A2 plays a pivotal role in maintaining vitamin C homeostasis within specific tissues. By actively transporting vitamin C into cells it ensures adequate antioxidant protection and collagen synthesis which are essential for tissue repair and immune function. As part of its biological role SLC23A2 does not associate with larger protein complexes but operates as an individual transporter to perform its function effectively.

Pathways

The activity of SLC23A2 is integrated into the ascorbate and aldarate metabolism pathway. It is closely related to the recycling of ascorbate impacting the body's ability to counteract oxidative stress. Additionally SLC23A2 works alongside other transport proteins such as SLC23A1 contributing to overall vitamin C homeostasis and impacting the function of the oxidative stress response pathway.

SLC23A2 has been implicated in conditions linked to vitamin C deficiency and oxidative damage. Disorders such as scurvy and neurodegenerative diseases have shown associations with altered SLC23A2 function. The transporter’s interactions with proteins involved in neuronal health and oxidative stress response suggest its potential involvement in these disorders. Understanding SLC23A2’s role in these conditions could provide therapeutic insights into managing related oxidative stress and tissue integrity issues.
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Specifications

Form

Lyophilized

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General info

Function

Sodium/ascorbate cotransporter (PubMed : 10471399, PubMed : 10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed : 10471399).

Sequence similarities

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.

Post-translational modifications

Phosphorylated.

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Product protocols

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Target data

Sodium/ascorbate cotransporter (PubMed : 10471399, PubMed : 10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed : 10471399).
See full target information SLC23A2
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Complementary Products

Primary Antibodies

AB229802

Anti-SLC23A2 antibody

Western blot - Anti-SLC23A2 antibody (AB229802)

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