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AB152862

Recombinant Human SLC25A11 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human SLC25A11 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

SLC20A4, SLC25A11, Mitochondrial 2-oxoglutarate/malate carrier protein, Alpha-oxoglutarate carrier, OGCP, Solute carrier family 25 member 11

1 Images
SDS-PAGE - Recombinant Human SLC25A11 protein (GST tag N-Terminus) (AB152862)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SLC25A11 protein (GST tag N-Terminus) (AB152862)

12.5% SDS-PAGE analysis of ab152862 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q02978

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB68167

Anti-Sarcomeric Alpha Actinin antibody [EP2529Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody [EP2529Y] (AB68167)

  • 5
  • 9
Primary Antibodies

AB32362

Anti-Desmin antibody [Y66] - Cytoskeleton Marker

RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Desmin antibody [Y66] - Cytoskeleton Marker (AB32362)

  • 5
  • 12
Primary Antibodies

AB15277

Anti-Dystrophin antibody

Immunohistochemistry - Anti-Dystrophin antibody (AB15277)

  • 4
  • 23
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG","proteinLength":"Full Length","predictedMolecularWeight":"60.28 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q02978","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SLC25A11 protein also known as the mitochondrial 2-oxoglutarate/malate carrier protein plays an important role in transporting substrates across the inner mitochondrial membrane. It specifically facilitates the exchange of 2-oxoglutarate and malate between the mitochondria and the cytosol. SLC25A11 has a molecular mass of approximately 33 kDa. Expression of SLC25A11 occurs across various tissues with significant levels in the liver and skeletal muscle where high energy turnover is required.
Biological function summary

SLC25A11 is integral to mitochondrial function and energy metabolism. It is part of a transporter complex involved in the tricarboxylic acid (TCA) cycle supporting the conversion of nutrients into energy. This process is essential for maintaining the cellular energy levels needed for various physiological functions. The efficient transport of 2-oxoglutarate and malate helps in balancing the redox and carbon status in cells contributing to overall cellular homeostasis.

Pathways

SLC25A11 is essential in the TCA cycle and the malate-aspartate shuttle. These pathways are vital for energy production and the regulation of cellular metabolism. In the TCA cycle SLC25A11 works closely with other proteins like isocitrate dehydrogenase participating in the decarboxylation and oxidation processes. In the malate-aspartate shuttle SLC25A11 collaborates with malate dehydrogenase enabling effective NADH transfer into the mitochondria a critical step for ATP generation.

SLC25A11 is linked to metabolic and mitochondrial disorders. Mutations or dysfunction in SLC25A11 can contribute to conditions such as mitochondrial diseases where energy production is impaired. This protein also shows associations with some forms of cancer where altered metabolism is a hallmark. Connections with other proteins like fumarate hydratase highlight its role in pathways that when disrupted may lead to disease progression.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed : 25637873, PubMed : 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed : 38937634). Does not transport glutathione (PubMed : 25637873). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed : 21448454). Involved in the regulation of apoptosis (By similarity).

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Subcellular localisation

Mitochondrion inner membrane

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Product protocols

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Target data

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed : 25637873, PubMed : 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed : 38937634). Does not transport glutathione (PubMed : 25637873). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed : 21448454). Involved in the regulation of apoptosis (By similarity).
See full target information SLC25A11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 34:102060 PubMed38028197

2023

Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.

Applications

Unspecified application

Species

Unspecified reactive species

Naoko Shiba,Xiao Yang,Mitsuto Sato,Shin Kadota,Yota Suzuki,Masahiro Agata,Kohei Nagamine,Masaki Izumi,Yusuke Honda,Tomoya Koganehira,Hideki Kobayashi,Hajime Ichimura,Shinichiro Chuma,Junichi Nakai,Shugo Tohyama,Keiichi Fukuda,Daigo Miyazaki,Akinori Nakamura,Yuji Shiba
View all publications
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