Recombinant Human Ferroportin protein (GST tag N-Terminus)

General info

Function

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).

Sequence similarities

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Post-translational modifications

Polyubiquitinated by RNF217; leading to proteasomal degradation (By similarity). Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells (PubMed:22682227, PubMed:37277838).