Recombinant Human SLC45A2 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC45A2 also known as the membrane-associated transporter protein (MATP) is an integral membrane protein with a mass of approximately 67 kDa. It functions mechanically by transporting molecules across cell membranes specifically facilitating the transport of melanin-related compounds in melanocytes which are pigment cells in the skin. SLC45A2 is expressed notably in the skin eyes and hair follicles aligning its function with pigmentation processes.

Biological function summary

SLC45A2 plays a critical role in melanin synthesis within the melanosomes the organelles where melanin is produced and stored. It is responsible for regulating pH levels and ion balance within these organelles helping control the environment necessary for the function of tyrosinase an important enzyme in melanin production. Although not part of a complex SLC45A2's activity is integral to maintaining proper melanocyte health and function in the skin.

Pathways

SLC45A2 is essential in the melanin biosynthesis pathway where it influences tyrosinase activity by affecting melanosomal pH. This interaction aids in the conversion of tyrosine to melanin which is a major process in pigmentation. Additionally SLC45A2 associates with the MC1R signaling pathway which regulates melanocyte response to external signals highlighting the interconnected nature of pigment production mechanisms in the body.

Defects in SLC45A2 are linked to oculocutaneous albinism type 4 (OCA4) a condition characterized by reduced melanin production in the skin hair and eyes leading to lighter pigmentation and vision problems. The target also has relevance in melanoma a form of skin cancer where abnormal melanocyte function drives uncontrolled cell growth. Here SLC45A2 can potentially interact with proteins like MITF a transcription factor that regulates melanocyte activity and survival impacting the progression of pigmentation-related diseases.