Recombinant Human SLC51B protein (His tag N-Terminus)
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Recombinant Human SLC51B protein (His tag N-Terminus) is a Human Fragment protein, in the 57 to 128 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
OSTB, SLC51B, Organic solute transporter subunit beta, OST-beta, Solute carrier family 51 subunit beta
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human SLC51B protein (His tag N-Terminus) (AB171468)
15% SDS-PAGE analysis of ab171468 (3μg).
Reactivity data
Product details
SLC51B, as known as OSTB, is an organic solute transporter subunit. SLC51 is composed of two distinct proteins that must heterodimerize to generate transport activity, but the role of the individual subunits in mediating transport activity is unknown. The results demonstrate that SLC51B is required for both proper trafficking of SLC51A and formation of the functional transport unit, and identify specific residues of SLC51B critical for these processes. Recombinant human SLC51B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
This product was previously labelled as OST-beta
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SLC51B plays an important role in enterohepatic circulation by facilitating the transport of bile acids and steroids. It works as part of a transporter complex when combined with OST-alpha enhancing transport efficiency. This function helps in maintaining bile acid homeostasis and supports lipid digestion and absorption. SLC51B's activity assists in controlling cholesterol levels and prevents the accumulation of toxic bile acid concentrations within cells.
Pathways
The activity of SLC51B is integral to the enterohepatic bile acid recycling pathway and lipid metabolism pathways. It collaborates with proteins like NTCP and ASBT which are important for bile acid uptake in hepatocytes and enterocytes respectively. These pathways ensure efficient bile acid transport beginning from the liver its reabsorption in the intestines and return to the liver illustrating its central role in maintaining metabolic balance.
Specifications
Form
Liquid
Additional notes
ab171468 is purified using conventional chromatography techniques.
General info
Function
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed : 16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed : 16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed : 16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed : 16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity).
Sequence similarities
Belongs to the OST-beta family.
Target data
Complementary Products
Product promise
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