Recombinant Human SLC6A20 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC6A20 also known as solute carrier family 6 member 20 or sodium- and chloride-dependent transporter plays an important mechanical role in transporting amino acids and related molecules across cell membranes. This protein weighs approximately 74 kDa and is mainly found in the kidneys brain and small intestine. SLC6A20 achieves transport by utilizing sodium and chloride gradients contributing to concentration regulation within cells. Its functional activity supports the balance of certain amino acids including proline which is important for cellular metabolism.

Biological function summary

In the context of physiological processes SLC6A20 participates in the regulation of amino acid homeostasis which is fundamental to proper metabolic function. It functions as part of transport systems essential for maintaining nutrient absorption. SLC6A20 often exists alongside other transporter proteins enabling it to work in harmony within the same physiological niche coordinating to manage cellular nutrient levels effectively.

Pathways

Several cellular processes depend on the correct operation of SLC6A20 including amino acid and neurotransmitter transport. One significant biological pathway involving SLC6A20 is the proline transport pathway where it interacts with proteins such as SNAT2 another amino acid transporter. These interactions align with fluid regulation and neurotransmitter cycling influencing cellular signaling processes.

Alterations in SLC6A20 activities relate directly to conditions like hyperprolinemia a metabolic disorder characterized by excess proline due to impaired transport. Furthermore SLC6A20 has associations with the immunological disorder sitosterolemia as changes in this transporter's function might influence amino acid concentrations impacting immune responses. Connections with proteins like ORAI1 further suggest links to these disease mechanisms emphasizing SLC6A20's important role in disease progression.