Recombinant Human SLC7A9 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

SLC7A9 facilitates the selective transepithelial transport of amino acids through its association with the heavy chain rBAT forming a functional heteromeric complex. This complex ensures effective transport of specific amino acids particularly cystine and dibasic amino acids from the lumen into epithelial cells which is critical for preventing loss of these amino acids in urine. This biological role is integral to maintaining amino acid levels and systemic nitrogen economy highlighting its importance in everyday metabolism.

Pathways

SLC7A9 activity interacts notably within the cystine and arginine metabolism pathways. Here its transporter function complements the action of other solute carriers and enzymes like SLC3A1 its associated partner in the heterodimeric complex to modulate amino acid concentrations within systemic circulation. SLC7A9 also influences the lysine degradation pathway which involves the cellular regulation of lysine levels interplaying with enzymes such as lysine-ketoglutarate reductase to maintain metabolic homeostasis.