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AB276254

Recombinant Human Slitrk1 protein (Fc Chimera His Tag)

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Recombinant Human Slitrk1 protein (Fc Chimera His Tag) is a Human Fragment protein, in the 1 to 616 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

KIAA1910, LRRC12, UNQ233/PRO266, SLITRK1, SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12

1 Images
SDS-PAGE - Recombinant Human Slitrk1 protein (Fc Chimera His Tag) (AB276254)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Slitrk1 protein (Fc Chimera His Tag) (AB276254)

SDS-PAGE analysis of ab276254

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96PX8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 0.75% Glycine, 0.61% Tris, 0.06% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVS","proteinLength":"Fragment","predictedMolecularWeight":"95 kDa","actualMolecularWeight":null,"aminoAcidEnd":616,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96PX8","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Slitrk1 also known as SLIT and NTRK-like protein 1 is a transmembrane protein with a mass of approximately 95 kDa. It functions mechanically by interacting with neuronal cells to influence axonogenesis and synaptogenesis. Slitrk1 has a role in the nervous system where it is primarily expressed particularly in the brain. Its structure includes leucine-rich repeat (LRR) domains facilitating its interactions with the cellular environment and other molecules.
Biological function summary

Slitrk1 influences neural development and synapse formation playing a role in the regulation of synaptic strength. It may interact with the receptor protein tyrosine phosphatase sigma (PTPσ) forming a receptor-ligand pair critical for its function in neural contexts. This interaction contributes to promoting proper neuronal connections and maintaining synaptic plasticity which is essential for cognitive processes.

Pathways

The role Slitrk1 plays in neural development connects it to the neurotrophic signaling pathway. This pathway influences neuron survival development and function. Slitrk1 is also linked with the semaphorin-plexin signaling pathway which guides axon guidance and neuronal positioning. Proteins like neurotrophin receptor TrkC and plexins may relate to Slitrk1 within these pathways influencing its downstream signaling effects.

Genetic mutations in Slitrk1 have been associated with Tourette syndrome and trichotillomania. These conditions are neurodevelopmental indicating Slitrk1’s importance in the nervous system's proper function. Slitrk1's association with PTPσ in these disorders shows its potential as a therapeutic target as PTPσ's pathway disruption could contribute to the symptoms observed in these disorders.
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Specifications

Form

Lyophilized

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General info

Function

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed : 27273464, PubMed : 27812321). Enhances neuronal dendrite outgrowth (PubMed : 16224024, PubMed : 19640509).

Sequence similarities

Belongs to the SLITRK family.

Post-translational modifications

Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.

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Product protocols

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Target data

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed : 27273464, PubMed : 27812321). Enhances neuronal dendrite outgrowth (PubMed : 16224024, PubMed : 19640509).
See full target information SLITRK1
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Complementary Products

Primary Antibodies

AB67238

Anti-Slitrk1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Slitrk1 antibody (AB67238)

  • 0
  • 0
Assay Kits

AB314349

Human Slitrk ELISA Kit

Sandwich ELISA - Human Slitrk ELISA Kit (AB314349)

  • 0
  • 0

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