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AB276503

Recombinant Human SLITRK4 protein (His tag)

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Recombinant Human SLITRK4 protein (His tag) is a Human Fragment protein, in the 1 to 616 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

SLIT and NTRK-like protein 4, SLITRK4

1 Images
SDS-PAGE - Recombinant Human SLITRK4 protein (His tag) (AB276503)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SLITRK4 protein (His tag) (AB276503)

SDS-PAGE analysis of ab276503

Key facts

Purity

>92% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB67315

Anti-SLITRK4 antibody

Western blot - Anti-SLITRK4 antibody (AB67315)

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Sample Prep & Detection Kits

AB102903

PE/Cy7® Conjugation Kit - Lightning-Link®

Conjugation - PE/Cy7® Conjugation Kit - Lightning-Link® (AB102903)

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Proteins & Peptides

AB180346

Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus) (AB180346)

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Sample Prep & Detection Kits

AB201801

DyLight® 594 Conjugation Kit (Fast) - Lightning-Link®

Fluorescence Microscopy - DyLight® 594 Conjugation Kit (Fast) - Lightning-Link® (AB201801)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVP","proteinLength":"Fragment","predictedMolecularWeight":"68.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":616,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8IW52","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLITRK4 also known as SLIT and NTRK-like protein 4 is a protein involved in neural cell signaling. It is a member of the SLITRK family which consists of six known proteins that share structural similarities to both the Slit and Trk families of proteins. SLITRK4 has a molecular mass of approximately 104 kDa. This protein is highly expressed in the brain particularly in the thalamus region as well as in some other neural tissues. Its expression is less present in peripheral tissues indicating a more central nervous system-specific role.
Biological function summary

SLITRK4 plays an essential role in modulating synaptic activity and neuron-neuron communication. It is part of a transmembrane protein family interacting with other synaptic and intracellular proteins to coordinate signaling events that influence neuronal growth and connectivity. By regulating synaptic plasticity SLITRK4 contributes to the formation of functional neural circuits and is involved in the proper development and maintenance of synapses.

Pathways

SLITRK4 is integrally engaged in neurodevelopmental pathways particularly those governing neural circuit assembly and synaptic function. It interacts with proteins like leucine-rich repeat transmembrane neuronal proteins to facilitate synaptic adhesion and signaling processes. Additionally SLITRK4's role in synaptic modulation links it to pathways controlling neurotransmitter release and receptor signaling essential for effective communication between neurons.

SLITRK4 has shown associations with neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Disruptions in SLITRK4 can lead to misregulated synaptic function contributing to the pathophysiology of these conditions. Alterations in its expression or function may also affect interactions with related proteins like neurexins which are important for synaptic stability and network formation. Understanding these connections continues to provide insights into the molecular bases of these complex disorders.
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General info

Function

It is involved in synaptogenesis and promotes synapse differentiation (PubMed : 27812321). Suppresses neurite outgrowth (By similarity).

Sequence similarities

Belongs to the SLITRK family.

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Product protocols

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Target data

It is involved in synaptogenesis and promotes synapse differentiation (PubMed : 27812321). Suppresses neurite outgrowth (By similarity).
See full target information SLITRK4
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